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An inhalational anesthetic is a chemical compound possessing general anesthetic properties that is delivered via inhalation. They are administered through a face mask, laryngeal mask airway or tracheal tube connected to an anesthetic vaporiser and an anesthetic delivery system .
A lower MAC value represents a more potent volatile anesthetic. Other uses of MAC include MAC-BAR (1.7–2.0 MAC), which is the concentration required to block autonomic reflexes to nociceptive stimuli, and MAC-awake (0.3–0.5 MAC), the concentration required to block voluntary reflexes and control perceptive awareness.
Ketamine is the most widely anesthetic agent used for longer duration operations. After an intravenous therapy, which is about 2.2 mg/kg, mixed with the 1.1 mg/kg xylazine the half-life of xylazine is approximately 66 minutes and the clearance is around 31 mL/kg/min when patients are halothane-anesthetized. [20]
The more soluble the inhaled anesthetic is in blood compared to in air, the more it binds to plasma proteins in the blood and the higher the blood–gas partition coefficient. It is inversely related to induction rate. Induction rate is defined as the speed at which an agent produces anesthesia.
An anesthetic vaporizer (American English) or anaesthetic vapouriser (British English) is a device generally attached to an anesthetic machine which delivers a given concentration of a volatile anesthetic agent. It works by controlling the vaporization of anesthetic agents from liquid, and then accurately controlling the concentration in which ...
The Meyer-Overton correlation for anaesthetics. A nonspecific mechanism of general anaesthetic action was first proposed by Emil Harless and Ernst von Bibra in 1847. [9] They suggested that general anaesthetics may act by dissolving in the fatty fraction of brain cells and removing fatty constituents from them, thus changing activity of brain cells and inducing anaesthesia.
Sevoflurane is an inhaled anesthetic that is often used to induce and maintain anesthesia in children for surgery. [17] During the process of awakening from the medication, it has been associated with a high incidence (>30%) of agitation and delirium in preschool children undergoing minor noninvasive surgery. [ 17 ]
Halothane, sold under the brand name Fluothane among others, is a general anaesthetic. [5] It can be used to induce or maintain anaesthesia. [5] One of its benefits is that it does not increase the production of saliva, which can be particularly useful in those who are difficult to intubate. [5]