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Sclerosis (from Ancient Greek σκληρός (sklērós) ' hard ') is the stiffening of a tissue or anatomical feature, usually caused by a replacement of the normal organ-specific tissue with connective tissue. The structure may be said to have undergone sclerotic changes or display sclerotic lesions, which refers to the process of sclerosis.
Main symptoms of multiple sclerosis. MS lesions can affect any part of the central nervous system so a person with MS can have almost any neurological signs or symptoms. [26] Fatigue is one of the most common symptoms of MS. [27] [28] Roughly 65% of people with MS experience fatigue. Of these, some 15–40% report fatigue as their most ...
Pansclerotic morphea is manifested by sclerosis of the dermis, panniculus, fascia, muscle, and at times, the bone, all causing disabling limitation of motion of joints. [ 3 ] : 171 Linear scleroderma is a type of localised scleroderma [ 11 ] which is an autoimmune disease characterized by a line of thickened skin which can affect the bones and ...
Osteosclerosis is a disorder characterized by abnormal hardening of bone and an elevation in bone density. It may predominantly affect the medullary portion and/or cortex of bone.
Lipodermatosclerosis is most commonly diagnosed in middle-aged women. [ 3 ] The origin of lipodermatosclerosis is probably multifactorial, involving tissue hypoxia, leakage of proteins into the interstitium, and leukocyte activation.
Even sclerotic bone metastases are generally less radiodense than enostoses, and it has been suggested that bone metastasis should be the favored diagnosis between the two for bone lesions lower than a cutoff of 1060 Hounsfield units (HU). [11] If a biopsy is indicated, a CT scan is often used to localize the lesion before biopsy. [15]
Main symptoms of multiple sclerosis Symptoms and findings in multiple sclerosis. Multiple sclerosis can cause a variety of symptoms varying significantly in severity and progression among individuals: changes in sensation (hypoesthesia), muscle weakness, abnormal muscle spasms, or difficulty moving; difficulties with coordination and balance; problems in speech or swallowing (), visual ...
Multiple sclerosis is typically diagnosed based on the presenting signs and symptoms, in combination with supporting medical imaging and laboratory testing. [4] It can be difficult to confirm, especially early on, since the signs and symptoms may be similar to those of other medical problems.