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Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. [6] For osteoporosis it is less preferred than bisphosphonates. [6] It is also used to reduce the risk of breast cancer in those at high risk. [6] It is taken by mouth. [6]
When the interactive distance between raloxifene and Asp-351 is increased from 2.7 Å to 3.5-5 Å it causes increased estrogen-like action of the raloxifene-ERα complex. When the piperidine ring of raloxifene is replaced by cyclohexane, the ligand loses antiestrogenic properties and becomes a full agonist. The interaction between SERM's ...
[7] [8] The second single "Krabby Step" was released on November 5, 2020, [9] performed by Swae Lee, Tyga and Lil Mosey. [10] The soundtrack was released on March 5, 2021, a day after the film's premiere. [11] [12] Hans Zimmer signed on to compose the original score in October 2018, [13] with his protégé Steve Mazzaro serving as co-composer. [14]
The video game SpongeBob's Truth or Square that was based on the SpongeBob SquarePants television special was released for PlayStation Portable, [47] Wii, [48] Xbox 360, [49] and Nintendo DS. [50] The game was first announced by THQ on May 21, 2009, and was originally titled SpongeBob SquarePants: Happiness Squared before being changed early in ...
In a 2019 ranking of SpongeBob's top 100 episodes, TV Guide listed "Mid-Life Crustacean" as the 79th best episode. [8] Allegra Frank at Slate commented in 2021 "...as a nostalgia buff who looks to Paramount+ solely to sate that need, seeing a small piece of SpongeBob history be stripped away by its parent company is jarring. There are tons of ...
The antiestrogen withdrawal response is a paradoxical improvement in breast cancer caused by discontinuation of antiestrogen therapy for breast cancer. [1] [2] [3] [4 ...
Episodes of SpongeBob SquarePants have been nominated for a variety of different awards, including 17 Annie Awards (with six wins), [10] 17 Golden Reel Awards (with eight wins), [11] 15 Emmy Awards (with one win), [12] 22 Kids' Choice Awards (with 21 wins), [13] and four BAFTA Children's Awards (with two wins). [14] Several compilation DVDs ...
Estradiol was used as a positive control and raloxifene was used because it is in the same drug class as ospemifene. [10] Multiple doses of oral ospemifene were tested. [10] 10 mg/kg/day of Ospemifene was found to cause a greater increase in vaginal weight and vaginal epithelial height than 10 mg/kg/day of raloxifene. [10]