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Raloxifene, sold under the brand name Evista among others, is a medication used to prevent and treat osteoporosis in postmenopausal women and those on glucocorticoids. [6] For osteoporosis it is less preferred than bisphosphonates. [6] It is also used to reduce the risk of breast cancer in those at high risk. [6] It is taken by mouth. [6]
The SpongeBob SquarePants video game series is a collection of video games and arcade games based on the Nickelodeon animated television series SpongeBob SquarePants and its film series with the same name. The television series' massive rise in popularity during the 2000s led to a myriad of video games that span different genres.
Based on the Nickelodeon animated series SpongeBob SquarePants, it is a remake of the console versions of Heavy Iron Studios' SpongeBob SquarePants: Battle for Bikini Bottom (2003). It is the first major game in the series since SpongeBob HeroPants (2015) and the first since the death of the show's creator Stephen Hillenburg in 2018.
The story follows Plankton, whose plans for world domination are put to a halt when his computer wife, Karen, decides to take charge. It is the second in a series of SpongeBob character spin-off films following the first in 2024. The film was originally conceived by Lawrence as a half-hour special, but was eventually put into development as a ...
The video game SpongeBob's Truth or Square that was based on the SpongeBob SquarePants television special was released for PlayStation Portable, [47] Wii, [48] Xbox 360, [49] and Nintendo DS. [50] The game was first announced by THQ on May 21, 2009, and was originally titled SpongeBob SquarePants: Happiness Squared before being changed early in ...
The antiestrogen withdrawal response is a paradoxical improvement in breast cancer caused by discontinuation of antiestrogen therapy for breast cancer. [1] [2] [3] [4 ...
In a 2019 ranking of SpongeBob's top 100 episodes, TV Guide listed "Mid-Life Crustacean" as the 79th best episode. [8] Allegra Frank at Slate commented in 2021 "...as a nostalgia buff who looks to Paramount+ solely to sate that need, seeing a small piece of SpongeBob history be stripped away by its parent company is jarring. There are tons of ...
Estradiol was used as a positive control and raloxifene was used because it is in the same drug class as ospemifene. [10] Multiple doses of oral ospemifene were tested. [10] 10 mg/kg/day of Ospemifene was found to cause a greater increase in vaginal weight and vaginal epithelial height than 10 mg/kg/day of raloxifene. [10]