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Most commonly, infections occur with inflammation of other parts of the respiratory tract, such as the larynx and bronchi, known as croup, [11] [10] however bacterial infections may also affect the trachea alone, although they are often associated with a recent viral infection. [10]
The infection begins in the trachea where it colonises and spreads to the bronchi. The characteristic increased sputum produced can give problems in the removal of the tracheal tube (extubation). Tracheobronchial infections are responsible for up to 80% of exacerbations in chronic obstructive pulmonary disease. [2]
A collapsed trachea is formed as a result of defect in the cartilage, that makes the cartilage unable to support the trachea and results in dry hacking cough. In this condition there can be inflammation of the linings of the trachea. If the connective nerve tissues in the trachea degenerate it causes tracheomalacia.
Fitz-Hugh–Curtis syndrome occurs almost exclusively in women, though it can be seen in males rarely. [5] It is complication of pelvic inflammatory disease (PID) caused by Chlamydia trachomatis (Chlamydia) or Neisseria gonorrhoeae (Gonorrhea) though other bacteria such as Bacteroides, Gardnerella, E. coli and Streptococcus have also been found to cause Fitz-Hugh–Curtis syndrome on occasion. [6]
Tonsillitis is swelling of the tonsils by a bacterial or viral infection. This inflammation can lead to airway obstruction. From tonsillitis can come a peritonsillar abscess which is the most common upper airway infection and occurs primarily in young adults. It causes swelling in one of the tonsils, pushing the uvula to the unaffected side. [9]
The causes of upper airway obstructions can be acute or chronic. More acute causes of upper airway obstruction include foreign body aspiration, blunt trauma to the neck, infections, and swelling due to allergies or other inflammatory conditions. [3] In children, viral infections such as croup or epiglottitis are frequent causes. [4]
Laryngotracheal stenosis is an umbrella term for a wide and heterogeneous group of very rare conditions. The population incidence of adult post-intubation laryngotracheal stenosis which is the commonest benign sub-type of this condition is approximately 1 in 200,000 adults per year. [10]
The mucosal lining of the trachea may also be injured by inhalation of hot gases or harmful fumes such as chlorine gas. [17] This can lead to edema (swelling), necrosis (death of the tissue), scar formation, and ultimately stenosis. [17] However, TBI due to inhalation, foreign body aspiration, and medical procedures is uncommon. [17]