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Acquired generalized lipodystrophy (AGL), also known as Lawrence syndrome [1] and Lawrence–Seip syndrome, [1] is a rare skin condition that appears during childhood or adolescence, characterized by fat loss affecting large areas of the body, particularly the face, arms, and legs.
Lipodystrophy syndromes are a group of genetic or acquired disorders in which the body is unable to produce and maintain healthy fat tissue. [ 1 ] [ 2 ] The medical condition is characterized by abnormal or degenerative conditions of the body's adipose tissue .
Congenital generalized lipodystrophy (also known as Berardinelli–Seip lipodystrophy) is an extremely rare autosomal recessive condition, characterized by an extreme scarcity of fat in the subcutaneous tissues. [2] It is a type of lipodystrophy disorder where the magnitude of fat loss determines the severity of metabolic complications. [3]
How Not to Die: Discover the Foods Scientifically Proven to Prevent and Reverse Disease is a book by Michael Greger, M.D. with Gene Stone, published in 2015 that argues for the health benefits of a whole food plant-based diet. [1] The book was a New York Times Best Seller. [2]
Corticosteroid-induced lipodystrophy (CIL) is a condition of abnormal fat deposition caused by corticosteroid medications. [1] Fat accumulates in the facial area (" moon face "), dorsocervical region ("buffalo hump"), and abdominal area ("pot belly" or "beer belly"), whereas the thickness of subcutaneous fat in the limbs is decreased. [ 1 ]
Reverse dieting trains your metabolism post-diet to prevent weight gain. It involves adding back 50 to 100 calories of protein per day in weekly steps to maintain weight.
E.g., Nitisinone prevents the formation of toxic metabolites for patients with Tyrosinemia Type I and enables normal growth and development in combination with a low-protein diet; Vitamins. E.g., thiamine supplementation benefits several types of disorders that cause lactic acidosis.
In general, treatment for acquired partial lipodystrophy is limited to cosmetic, dietary, or medical options. [9] Currently, no effective treatment exists to halt its progression. Diet therapy has been shown to be of some value in the control of metabolic problems.