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Pepsin is expressed as a zymogen called pepsinogen, whose primary structure has an additional 44 amino acids compared to the active enzyme. In the stomach, gastric chief cells release pepsinogen. This zymogen is activated by hydrochloric acid (HCl), which is released from parietal cells in the stomach lining.
n/a Ensembl ENSG00000229859 n/a UniProt P0DJD8 n/a RefSeq (mRNA) NM_001079807 n/a RefSeq (protein) NP_001073275 n/a Location (UCSC) Chr 11: 61.2 – 61.21 Mb n/a PubMed search n/a Wikidata View/Edit Human Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. Function This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the ...
n/a Ensembl ENSG00000256713 n/a UniProt P0DJD9 n/a RefSeq (mRNA) NM_014224 n/a RefSeq (protein) NP_055039 n/a Location (UCSC) Chr 11: 61.24 – 61.25 Mb n/a PubMed search n/a Wikidata View/Edit Human Pepsinogen A is a protein that in humans is encoded by the PGA5 gene. References ^ a b c GRCh38: Ensembl release 89: ENSG00000256713 - Ensembl, May 2017 ^ "Human PubMed Reference:". National ...
The enzyme is first made in the inactive form, pepsinogen by chief cells in the lining of the stomach. [24] With an impulse from the vagus nerve, pepsinogen is secreted into the stomach, where it mixes with hydrochloric acid to form pepsin. [25] Once active, pepsin works to break down proteins in foods such as dairy, meat, and eggs. [24]
The oxyntic gland contains the parietal cells that produce hydrochloric acid and intrinsic factor, and chief cells that produce pepsinogen and gastric lipase. The pyloric gland is found in the pyloric region, the remaining 20 per cent of the stomach. The pyloric glands are mainly in the pyloric antrum. The pyloric gland secretes gastrin from ...
Chief cells are part of fundic gland polyps (here shown in high magnification). [11]In gastric tissue, a loss of parietal cells due to chronic inflammation has been shown to affect chief cell differentiation and can induce chief cells to transdifferentiate back into neck cells and can lead to the formation of mucus cell metaplasia known as spasmolytic polypeptide expressing metaplasia (SPEM ...
The gastrointestinal hormones (or gut hormones) constitute a group of hormones secreted by enteroendocrine cells in the stomach, pancreas, and small intestine that control various functions of the digestive organs.
Digestion is the breakdown of large insoluble food compounds into small water-soluble components so that they can be absorbed into the blood plasma.In certain organisms, these smaller substances are absorbed through the small intestine into the blood stream.