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Mood stabilizers are best known for the treatment of bipolar disorder, [1] preventing mood shifts to mania (or hypomania) and depression. Mood stabilizers are also used in schizoaffective disorder when it is the bipolar type. [2]
Lamotrigine (Lamictal) is an anticonvulsant that can be used as a mood stabilizer to treat BP-II. The most common pharmacologic agents utilized in the treatment of BP-II includes mood stabilizers, antipsychotics, and antidepressants. [1]
Antipsychotics and mood stabilizers used together are quicker and more effective at treating mania than either class of drug used alone. Some analyses indicate antipsychotics alone are also more effective at treating acute mania. [12] A first-line treatment for depression in bipolar disorder is a combination of olanzapine and fluoxetine. [139]
Atypical antipsychotics include: Amisulpride (Solian) – approved in low doses as a monotherapy for persistent depression. Lumateperone (Caplyta) – approved as a monotherapy for bipolar depression. Lurasidone (Latuda) – approved as a monotherapy for bipolar depression. Quetiapine (Seroquel) – approved as a monotherapy for bipolar depression.
The drug seems ineffective in the treatment of current rapid-cycling, acute mania, or acute depression in bipolar disorder. [25] Lamotrigine has been shown to be as effective as lithium, the standard treatment for bipolar disorder. [26] Lamotrigine has not demonstrated clear efficacy in treating acute mood episodes, either mania or depression.
Certain lithium compounds, also known as lithium salts, are used as psychiatric medication, [4] primarily for bipolar disorder and for major depressive disorder. [4] Lithium is taken orally (by mouth). [4] Common side effects include increased urination, shakiness of the hands, and increased thirst. [4]
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