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In 1968 it took the form and became known as the neuroendocrine theory of aging. [38] [39] [40] 1956 Denham Harman proposed the free-radical theory of aging and demonstrated that free radical reactions contribute to the degradation of biological systems. [41] The theory is based on the ideas of Rebeca Gerschman and her colleagues put forward in ...
The activity theory of aging, also known as the implicit theory of aging, normal theory of aging, and lay theory of aging, proposes that aging occurs with more positive outcomes when adults stay active and maintain social interactions as they get older. [1] Activity theory suggests that the aging process is slowed or delayed, and quality of ...
Gerontology (/ ˌ dʒ ɛr ən ˈ t ɒ l ə dʒ i / JERR-ən-TOL-ə-jee) is the study of the social, cultural, psychological, cognitive, and biological aspects of aging.The word was coined by Ilya Ilyich Mechnikov in 1903, from the Greek γέρων (gérōn), meaning "old man", and -λογία (), meaning "study of".
As aging is the primary risk factor for major human diseases, including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases, it is important to describe and classify the types of changes that it entails. After a decade, the authors of the heavily cited original paper updated the set of proposed hallmarks in January 2023.
The free radical theory of aging states that organisms age because cells accumulate free radical damage over time. [ 1 ] A free radical is any atom or molecule that has a single unpaired electron in an outer shell. [ 2 ] While a few free radicals such as melanin are not chemically reactive, most biologically relevant free radicals are highly ...
The reliability theory of aging is an attempt to apply the principles of reliability theory to create a mathematical model of senescence.The theory was published in Russian by Leonid A. Gavrilov and Natalia S. Gavrilova as Biologiia prodolzhitelʹnosti zhizni in 1986, and in English translation as The Biology of Life Span: A Quantitative Approach in 1991.
Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. [ 1 ] In a broader sense, ageing can refer to single cells within an organism which have ceased ...
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal Biogerontology in 2000. It involves interdisciplinary research on the ...