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Empagliflozin, sold under the brand name Jardiance (/ ˈ dʒ ɑːr d i ə n s / JAR-dee-əns), among others, is an antidiabetic medication used to improve glucose control in people with type 2 diabetes. [12] [2] [14] It is taken by mouth. [2]
The mechanism of action on a cellular level is not well understood. Work is underway to define this mechanism as a prodiuretic with great promise. However, it has been shown that binding of different sugars to the glucose site affects the orientation of the aglycone in the access vestibule. So when the aglycone binds it affects the entire ...
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The See Clearly Method was an eye-exercise program that was marketed as an alternative to the use of glasses, contact lenses, and eye surgery to improve vision. Sales were halted by legal action in 2006. The method is not supported by basic science, and no research studies were conducted prior to marketing.
The eye exercises used in vision therapy can generally be divided into two groups: those employed for "strabismic" outcomes and those employed for "non-strabismic" outcomes, to improve eye health. Ophthalmologists and orthoptists do not endorse these exercises as having clinically significant validity for improvements in vision.
In the trial, Jardiance cut the combined risk of cardiovascular death or hospitalization from heart failure in HFpEF patients with or without diabetes. At the 26-month mark, 13.8% of Jardiance ...
Thiazolidinedione ligand dependent transactivation is responsible for the majority of anti-diabetic effects. The activated PPAR/RXR heterodimer binds to peroxisome proliferator hormone response elements upstream of target genes in complex with a number of coactivators such as nuclear receptor coactivator 1 and CREB binding protein, this causes upregulation of genes (for a full list see PPARγ):
The Bates method is an ineffective and potentially dangerous alternative therapy aimed at improving eyesight.Eye-care physician William Horatio Bates (1860–1931) held the erroneous belief that the extraocular muscles caused changes in focus and that "mental strain" caused abnormal action of these muscles; hence he believed that relieving such "strain" would cure defective vision.
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