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There are two kinds of neurons involved in the transmission of any signal through the sympathetic system: pre-ganglionic and post-ganglionic. The shorter preganglionic neurons originate in the thoracolumbar division of the spinal cord specifically at T1 to L2~L3, and travel to a ganglion, often one of the paravertebral ganglia, where they synapse with a postganglionic neuron.
Norepinephrine is synthesized from the amino acid tyrosine by a series of enzymatic steps in the adrenal medulla and postganglionic neurons of the sympathetic nervous system, while the norepinephrine that functions as a neurotransmitter in the brain is produced in the locus coeruleus, located in the pons of the brainstem. [11]
Beginning in the sympathetic nervous system, an external stimulus affects the adrenal medulla and causes a release of catecholamines. The sympathoadrenal system is a physiological connection between the sympathetic nervous system and the adrenal medulla and is crucial in an organism's physiological response to outside stimuli. [ 1 ]
Vascular smooth muscle is innervated primarily by the sympathetic nervous system through adrenergic receptors (adrenoceptors). The three types present are: alpha-1, alpha-2 and beta-2 adrenergic receptors|. The main endogenous agonist of these cell receptors is norepinephrine (NE).
The sympathetic trunk is a fundamental part of the sympathetic nervous system, and part of the autonomic nervous system. It allows nerve fibres to travel to spinal nerves that are superior and inferior to the one in which they originated. Also, a number of nerves, such as most of the splanchnic nerves, arise directly from the trunks.
A neural pathway connects one part of the nervous system to another using bundles of axons called tracts. The optic tract that extends from the optic nerve is an example of a neural pathway because it connects the eye to the brain; additional pathways within the brain connect to the visual cortex.
The sympathetic ganglia, or paravertebral ganglia, are autonomic ganglia of the sympathetic nervous system. Ganglia are 20,000 to 30,000 afferent and efferent nerve cell bodies that run along on either side of the spinal cord. Afferent nerve cell bodies bring information from the body to the brain and spinal cord, while efferent nerve cell ...
In the abdomen, general visceral afferent fibers usually accompany sympathetic efferent fibers. This means that a signal traveling in an afferent fiber will begin at sensory receptors in the afferent fiber's target organ, travel up to the ganglion where the sympathetic efferent fiber synapses, continue back along a splanchnic nerve from the ganglion into the sympathetic trunk, move into a ...