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Thiamine deficiency is a medical condition of low levels of thiamine (vitamin B 1). [1] A severe and chronic form is known as beriberi. [1] [7] The name beriberi was possibly borrowed in the 18th century from the Sinhalese phrase බැරි බැරි (bæri bæri, “I cannot, I cannot”), owing to the weakness caused by the condition.
this disease may even occur in some people with normal, or even high blood thiamine levels, or people with deficiencies in intracellular transport of this vitamin. [11] Selected genetic mutations, including presence of the X-linked transketolase-like 1 gene, SLC19A2 thiamine transporter protein mutations, and the aldehyde dehydrogenase-2 gene ...
The EARs for thiamine for women and men aged 14 and over are 0.9 mg/day and 1.1 mg/day, respectively; the RDAs are 1.1 and 1.2 mg/day, respectively. RDAs are higher than EARs to provide adequate intake levels for individuals with higher than average requirements. The RDA during pregnancy and for lactating females is 1.4 mg/day.
Smoking: Recent studies [14] suggest that smoking can lead to marginal biotin deficiency because it speeds up biotin catabolism (especially in women). [19] Excessive alcohol consumption [20] (causes a significant reduction in plasma biotin levels) Excessive consumption of antidiuretics or inadequate levels of antidiuretic hormone [21]
Alternatively, low levels of vitamin B 12 may increase the levels of proinflammatory proteins which may induce ischaemic stroke. [69] [70] It is important to screen vitamin B 12 deficiency in obese individuals, due to its importance in energy metabolism, and relationship with homocysteine and its potential to modulate weight gain. [63]
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Thiamine is a vitamin the body needs for growth, development, and cellular function, as well as converting food into energy. Thiamine is naturally present in some foods, added to some food products, and available as a dietary supplement. [13] A nutritional deficiency in thiamine can worsen alcohol-related brain damage.