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This illustration demonstrates the normal kidney physiology, including the Proximal Convoluted Tubule (PCT), Loop of Henle, and Distal Convoluted Tubule (DCT). It also includes illustrations showing where some types of diuretics act, and what they do. Renal physiology (Latin renes, "kidneys") is the study of the physiology of the kidney.
The foot processes have an actin-based cytoskeleton. [6] Podocytes are found lining the Bowman's capsules in the nephrons of the kidney. The pedicels or foot processes wrap around the glomerular capillaries to form the filtration slits. [7] The pedicels increase the surface area of the cells enabling efficient ultrafiltration. [8]
The glomerulus (pl.: glomeruli) is a network of small blood vessels (capillaries) known as a tuft, located at the beginning of a nephron in the kidney. Each of the two kidneys contains about one million nephrons. The tuft is structurally supported by the mesangium (the space between the blood vessels), composed of intraglomerular mesangial cells.
In renal physiology, ultrafiltration occurs at the barrier between the blood and the filtrate in the glomerular capsule (Bowman's capsule) in the kidneys. As in nonbiological examples of ultrafiltration, pressure (in this case blood pressure) and concentration gradients lead to a separation through a semipermeable membrane (provided by the ...
The kidney has many functions, which a well-functioning kidney realizes by filtering blood in a process known as glomerular filtration. A major measure of kidney function is the glomerular filtration rate (GFR). The glomerular filtration rate is the flow rate of filtered fluid through the kidney.
54631 Ensembl ENSG00000161270 ENSMUSG00000006649 UniProt O60500 Q9QZS7 RefSeq (mRNA) NM_004646 NM_019459 RefSeq (protein) NP_004637 NP_062332 Location (UCSC) Chr 19: 35.83 – 35.87 Mb Chr 7: 30.16 – 30.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Nephrin is a protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists ...
The size of the largest particles that can successfully pass through a filter is called the effective pore size of that filter. The separation of solid and fluid is imperfect; solids will be contaminated with some fluid and filtrate will contain fine particles (depending on the pore size, filter thickness and biological activity).
The renal corpuscle is composed of two structures, the glomerulus and the Bowman's capsule. [3] The glomerulus is a small tuft of capillaries containing two cell types. . Endothelial cells, which have large fenestrae, are not covered by dia