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Adie syndrome, also known as Holmes–Adie syndrome, is a neurological disorder characterized by a tonically dilated pupil that reacts slowly to light but shows a more definite response to accommodation (i.e., light-near dissociation). [1] It is frequently seen in females with absent knee or ankle jerks and impaired sweating.
Ross' syndrome consists of Adie's syndrome (myotonic pupils and absent deep tendon reflexes) plus segmental anhidrosis (typically associated with compensatory hyperhidrosis). [1] It was characterized in 1958 [2] [3] by A.T. Ross. [4] By 1992, eighteen cases had been documented. [5]
William John Adie MD Ed., FRCP (31 October 1886 – 17 March 1935) was an Australian-born British physician and neurologist known for describing the Adie syndrome and narcolepsy. Biography [ edit ]
The two different types of near response are caused by different underlying disease processes. Adie's pupil is caused by damage to peripheral pathways to the pupil (parasympathetic neurons in the ciliary ganglion that cause pupillary constriction to bright light and with near vision). The pathophysiologic mechanism which produces an Argyll ...
Adie tonic pupil: Tonic pupil is usually an isolated benign entity, presenting in young women. It may be associated with loss of deep tendon reflex (Adie's syndrome). Tonic pupil is characterized by delayed dilation of the iris, especially after near stimulus, segmental iris constriction, and sensitivity of pupil to a weak solution of pilocarpine.
The Marcus Gunn pupil is a relative afferent pupillary defect indicating a decreased pupillary response to light in the affected eye. [3]In the swinging flashlight test, a light is alternately shone into the left and right eyes.
Airborne disease, a disease that spreads through the air. Contagious disease, a subset of infectious diseases. Cryptogenic disease, a disease whose cause is currently unknown. Disseminated disease, a disease that is spread throughout the body. Environmental disease; Lifestyle disease, a disease caused largely by lifestyle choices.
Gordon Morgan Holmes' father was a successful farmer at Dellin House, Castlebellingham, County Louth, about 40 miles north of Dublin.The early death of his mother, Kathleen (née Morgan), and his father's remarriage, deeply affected Holmes, and although he had three brothers and three sisters, he was a solitary child.