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Metabolomics is the scientific study of chemical processes involving metabolites, the small molecule substrates, intermediates, and products of cell metabolism. Specifically, metabolomics is the "systematic study of the unique chemical fingerprints that specific cellular processes leave behind", the study of their small-molecule metabolite ...
The MSEA web server is a freely available web server for performing metabolite set enrichment analysis on human or mammalian metabolomics data. The required input is either a list of compound names or compound names and concentrations. The output is a set of graphs and tables with embedded hyperlinks to the pertinent pathway images and descriptors.
To begin a session on MetPA users must first have a list of significant compounds derived from a metabolomic tests or compounds and concentration data with information about the phenotype of the organisms under study. The list of compounds can include common names, HMDB IDs or KEGG IDs with one compound per row. Compound concentration tables ...
The first book on metabolomics was published in 2003. [5] The first journal dedicated to metabolomics (titled simply "Metabolomics") was launched in 2005 and is currently edited by Prof. Roy Goodacre. Some of the more significant early papers on metabolome analysis are listed in the references below. [6] [7] [8] [9]
Human Metabolome Database; Content; Description: Metabolomics database: Data types captured: Human metabolite structures, metabolite descriptions, metabolite reactions, metabolite enzymes and transporters, human enzyme and transporter sequences, human metabolic pathways, normal and abnormal metabolite concentrations in humans, associated diseases, chemical properties, nomenclature, synonyms ...
Diagram illustrating genomics. Omics is the collective characterization and quantification of entire sets of biological molecules and the investigation of how they translate into the structure, function, and dynamics of an organism or group of organisms.
Metabolic flux analysis (MFA) is an experimental fluxomics technique used to examine production and consumption rates of metabolites in a biological system. At an intracellular level, it allows for the quantification of metabolic fluxes, thereby elucidating the central metabolism of the cell. [1]
In principle, any technologies used for metabolomics can be used for exometabolomics. However, liquid chromatography–mass spectrometry (LC–MS) has been the most widely used. [ 3 ] As with typical metabolomic measurements, metabolites are identified based on accurate mass, retention time, and their MS/MS fragmentation patterns, in comparison ...