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The sheath is also responsible for multiple or accessory roots (medial growth) and lateral or accessory canals in the root (break in epithelium). [3] It is controversial, but HERS may be involved in cementogenesis and the secreting of cementum, or that HERS-derived products might be related to enamel-related molecules, and that these proteins might initiate acellular cementum formation.
The sheath is irregularly fragmented in time and space as it promotes cementum deposition on the newly formed dentin. After this fragmentation, Hertwig's epithelial root sheath also participates in cementogenesis and formation of the periodontal ligament, giving rise to the epithelial rests of Malassez
The mechanism of differentiation of the cementoblasts is controversial but circumstantial evidence suggests that an epithelium or epithelial component may cause dental sac cells to differentiate into cementoblasts, characterised by an increase in length. [1] Other theories involve Hertwig epithelial root sheath (HERS) being involved. [2]
For cementogenesis to begin, Hertwig epithelial root sheath (HERS) must fragment. HERS is a collar of epithelial cells derived from the apical prolongation of the enamel organ. Once the root sheath disintegrates, the newly formed surface of root dentin comes into contact with the undifferentiated cells of the dental sac (dental follicle).
The cervical loop is the location on an enamel organ in a developing tooth where the outer enamel epithelium and the inner enamel epithelium join. The cervical loop is a histologic term indicating a specific epithelial structure at the apical side of the tooth germ, consisting of loosely aggregated stellate reticulum in the center surrounded by ...
Root sheath may refer to any of these biological structures: Epithelial root sheath, a proliferation of epithelial cells located at the cervical loop of the enamel organ in a developing tooth; Root sheath (hair), at the base of a hair follicle Inner root sheath; Outer root sheath; Seed root sheath, root sheaths in the seeds of plants
Tooth development begins at week 6 in utero, in the oral epithelium. The process is divided into three stages: Initiation; Morphogenesis and; Histogenesis [2]; At the end of week 7 i.u., localised proliferations of cells in the dental laminae form round and oval swellings known as tooth buds, which will eventually develop into mesenchymal cells and surround the enamel organ.
In dentistry, the epithelial cell rests of Malassez (ERM) or epithelial rests of Malassez (pax epithelialis pediodontii) are part of the periodontal ligament cells around a tooth. They are discrete clusters of residual cells from Hertwig's epithelial root sheath (HERS) that didn't completely disappear.