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Hyperthermia is generally diagnosed by the combination of unexpectedly high body temperature and a history that supports hyperthermia instead of a fever. [2] Most commonly this means that the elevated temperature has occurred in a hot, humid environment (heat stroke) or in someone taking a drug for which hyperthermia is a known side effect ...
The resting human body generates about two-thirds of its heat through metabolism in internal organs in the thorax and abdomen, as well as in the brain. The brain generates about 16% of the total heat produced by the body. [8] Heat loss is a major threat to smaller creatures, as they have a larger ratio of surface area to volume.
Simplified control circuit of human thermoregulation. [8]The core temperature of a human is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system, [9] and more specifically by the anterior hypothalamic nucleus and the adjacent preoptic area regions of the hypothalamus.
High levels can be produced by cells in response to hyperthermia, oxidative stress, and changes in pH. Binding immunoglobulin protein (BiP or Grp78) is a protein localized to the endoplasmic reticulum. It is involved in protein folding there, and can be upregulated in response to stress or starvation. mtHsp70 or Grp75 is the mitochondrial Hsp70.
If the body is unable to maintain a normal human body temperature and it increases significantly above normal, a condition known as hyperthermia occurs. The opposite condition, when body temperature decreases below normal levels, is known as hypothermia. It occurs when the body loses heat faster than producing it.
The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme is found across a multitude of organisms, prokaryotes and eukaryotes alike, with the same general function, but in different structural forms suitable to the environment they function in. Alkaline phosphatase is found in the periplasmic ...
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation.
Hyperthermia is an elevation of body temperature over the temperature set point, due to either too much heat production or not enough heat loss. [1] [7] Hyperthermia is thus not considered fever. [7]: 103 [40] Hyperthermia should not be confused with hyperpyrexia (which is a very high fever). [7]: 102