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  2. Eosinophilia–myalgia syndrome - Wikipedia

    en.wikipedia.org/wiki/Eosinophilia–myalgia...

    Eosinophilia–myalgia syndrome is a rare, sometimes fatal neurological condition linked to the ingestion of the dietary supplement L-tryptophan. [1] [2] The risk of developing EMS increases with larger doses of tryptophan and increasing age. [3] Some research suggests that certain genetic polymorphisms may be related to the development of EMS. [4]

  3. Tryptophan - Wikipedia

    en.wikipedia.org/wiki/Tryptophan

    Tryptophan ball and stick model spinning. Tryptophan (symbol Trp or W) [3] is an α-amino acid that is used in the biosynthesis of proteins.Tryptophan contains an α-amino group, an α-carboxylic acid group, and a side chain indole, making it a polar molecule with a non-polar aromatic beta carbon substituent.

  4. Resonac - Wikipedia

    en.wikipedia.org/wiki/Resonac

    [8]: 327–328 Multiple epidemiological studies [7] [9] [10] traced an outbreak of eosinophilia-myalgia syndrome (EMS) to L-tryptophan supplied by Showa Denko, which resulted in 37 deaths. [11] [12] It was further hypothesized that one or more trace impurities produced during the manufacture of tryptophan may have been responsible for the EMS ...

  5. This type of supplement may increase heart disease risk, new ...

    www.aol.com/news/type-supplement-may-increase...

    The two investigations, one in the U.S. and one in Europe, showed that the niacin breakdown product, 4PY, predicted participants’ future risk of heart attack, stroke and death. The final part of ...

  6. List of withdrawn drugs - Wikipedia

    en.wikipedia.org/wiki/List_of_withdrawn_drugs

    Risk for heart valve damage. [2] Perhexiline: 1985 UK, Spain Neurologic and hepatic toxicity. [3] Phenacetin: 1975 Canada An ingredient in "A.P.C." tablet; withdrawn because of risk of cancer and kidney disease [42] Germany Denmark, UK, US, others Reason: nephropathy. [3] Phenformin and Buformin: 1977 France, Germany US Severe lactic acidosis ...

  7. Indoxyl sulfate - Wikipedia

    en.wikipedia.org/wiki/Indoxyl_sulfate

    Indoxyl sulfate, also known as 3-indoxylsulfate and 3-indoxylsulfuric acid, is a metabolite of dietary L-tryptophan that acts as a cardiotoxin and uremic toxin. [1] [2] [3] High concentrations of indoxyl sulfate in blood plasma are known to be associated with the development and progression of chronic kidney disease and vascular disease in humans.

  8. This disease kills more people than all cancers and accidents ...

    www.aol.com/news/disease-kills-more-people...

    The report, which was published on Jan. 27 in the AHA’s journal Circulation, revealed that cardiovascular disease kills more people than all types of cancer and accidental deaths combined.

  9. 5-Hydroxytryptophan - Wikipedia

    en.wikipedia.org/wiki/5-Hydroxytryptophan

    5-HTP is produced from the amino acid tryptophan through the action of the enzyme tryptophan hydroxylase. Tryptophan hydroxylase is one of the biopterin-dependent aromatic amino acid hydroxylases. Production of 5-HTP is the rate-limiting step in 5-HT (serotonin) synthesis. 5-HTP is normally rapidly converted to 5-HT by amino acid decarboxylase. [1]