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Tetrahydrocannabinolic acid (THCA, 2-COOH-THC; conjugate base tetrahydrocannabinolate) is a precursor of tetrahydrocannabinol (THC), an active component of cannabis. [1]THCA is found in variable quantities in fresh, undried cannabis, but is progressively decarboxylated to THC with drying, and especially under intense heating such as when cannabis is smoked or cooked into cannabis edibles.
Other concerns include difficulties for drug testing due to novel metabolites, or high potency/binding affinity of isomers for cannabinoid receptors showing potential for abuse (i.e., THCP, which has 33× the binding affinity of Δ 9-THC) [70] [71] From 2021 to 2023, the Δ 8-THC market generated US$2 billion in revenue. [72]
This is a list of the world's largest cannabis companies by revenue.The list shows cannabis companies ranked by annual revenue. The list includes companies whose primary business activities are associated with cannabis.
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Heat is required to decarboxylate the non-psychoactive phytocannabinoid THCA to its psychoactive form, THC. Likewise, CBDA turns into CBD. From hemp plant material in an oven, cannabinoid concentration plots (time/temp) show THC: [16] STP 0 minutes 0.20mg/g; 140-160C 20 minutes 0.27mg/g; 140-160C 60 minutes 0.05-0.15mg/g
Trulieve is a business in the U.S. cannabis industry.It is considered the second largest in the segment, behind Curaleaf, with $1.2 billion in 2022 sales. [1] In 2021, after acquiring Canadian company Harvest, Trulieve became at the time the largest cannabis company in the world, [2] and claimed to be the most profitable.
Classical cannabinoids include nabilone and dronabinol, and one of the best known synthetic classical cannabinoids is HU-210. [85] HU-210 is a chiral compound first synthesized by Raphael Mechoulam at Hebrew University in the 1980s.
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