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In addition to the other side effects, the WHO researchers were concerned about gossypol's toxicity: the LD 50 in primates is less than 10 times the contraceptive dose, [14] creating a small therapeutic window. This report effectively ended further studies of gossypol as a temporary contraceptive, but research into using it as an alternative to ...
Pituitary pars intermedia dysfunction (PPID), or equine Cushing's disease, is an endocrine disease affecting the pituitary gland of horses. It is most commonly seen in older animals, [ 1 ] and is classically associated with the formation of a long, wavy coat ( hirsutism ) and chronic laminitis .
The fossa has several scent glands. Like herpestids it has a perianal skin gland inside an anal sac which surrounds the anus like a pocket. The pocket opens to the exterior with a horizontal slit below the tail. Other glands are located near the penis or vagina, with the penile glands emitting a strong odor. Like the herpestids, it has no ...
The effects of scopolamine were studied for use as a truth serum in interrogations in the early 20th century, [62] but because of the side effects, investigations were dropped. [63] In 2009, the Czechoslovak state security secret police were proven to have used scopolamine at least three times to obtain confessions from alleged antistate ...
In dogs, sheep, horses, and cattle, the half-life is very short: only 1.21– 5.97 minutes. Complete elimination of the drug can take up to 23 minutes in sheep and up to 49 minutes in horses. [1] [3] In young rats the half-life is one hour. [18] Xylazine has a large volume of distribution of V d = 1.9 – 2.5 for horses, cattle, sheep, and dogs ...
The Mayo Clinic suggests the following: antibiotics (generally the lowest side effect profile compared to other treatments); corticosteroids (e.g., prednisone); but corticosteroids have many side effects, including "moon face" for the duration of the medication's trial usage, as well as unwanted hair growth for females and/or osteoporosis with ...
Pheromone-containing secretions from the preorbital gland may serve to establish an animal's dominance (especially in preparation for breeding), [4] mark its territory, or simply to produce a pleasurable sensation to the animal. [5] Because of its critical role in scent marking, the preorbital gland is usually considered as a type of scent gland.
Drug testing of racehorse urine has led to the revelation that among levamisole equine metabolites are both pemoline and aminorex, stimulants that are forbidden by racing authorities. [ 24 ] [ 25 ] [ 26 ] Further testing confirmed aminorex in human and canine urine, meaning that both humans and dogs also metabolize levamisole into aminorex ...