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As a consequence of the inability of PBP2a to interact with β-lactam moieties, acquisition of mecA confers resistance to all β-lactam antibiotics in addition to methicillin. [43] [51] mecA is under the control of two regulatory genes, mecI and mecR1. MecI is usually bound to the mecA promoter and functions as a repressor. [41] [44] In the ...
SCCmec, or staphylococcal cassette chromosome mec, is a mobile genetic element of Staphylococcus bacterial species. This genetic sequence includes the mecA gene coding for resistance to the antibiotic methicillin and is the only known way for Staphylococcus strains to spread the gene in the wild by horizontal gene transfer. [1]
Meca or MECA may refer to: Biology. mecA, responsible for methicillin resistance in MRSA; Meca, a snout moth genus in the subfamily Pyralinae; Places Meca ...
There is an increasing prevalence of antibiotic resistance in S. pseudintermedius, specifically to methicillin, which makes it challenging to treat in humans. [44] [42] [41] Veterinary dermatologists are exposed to animals with skin and soft infections that commonly possess MRSP (methicillin‐resistant Staphylococcus pseudintermedius).
The mecA gene is carried by a mobile genetic element called the staphylococcal cassette chromosome mec (SCCmec) which is thought to promote spread between different species. [58] The presence of the mecA gene, expression of PBP2a, and methicillin resistance has been reported in S. schleiferi isolates. [13]
Presence of the protein penicillin binding protein 2A (PBP2A) is responsible for the antibiotic resistance seen in methicillin-resistant Staphylococcus aureus (MRSA). [11] The β-lactam ring is a structure common to all β-lactam antibiotics. [12]
MRSA ST398 (Methicillin-resistant Staphylococcus aureus ST398) is a specific strain of Methicillin-resistant Staphylococcus aureus (MRSA). Staphylococcus aureus is a gram-positive, spherical bacterium that can cause a range of infections in humans and animals.
Methicillin-resistant Staphylococcus aureus is an increasing cause of VAP. As many as fifty percent of Staphylococcus aureus isolates in the intensive care setting are resistant to methicillin. Resistance is conferred by the mecA gene.