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Light sensitivity or photosensitivity refers to a notable or increased reactivity to light. Apart from vision , human beings have many physiological and psychological responses to light. In rare individuals an atypical response may result in serious discomfort, disease, or injury.
Photosensitivity is the amount to which an object reacts upon receiving photons, especially visible light. In medicine, the term is principally used for abnormal reactions of the skin, and two types are distinguished, photoallergy and phototoxicity .
S cones respond most strongly to blue short-wavelength light, peaking at 420 nm, and make up only around 2% of the cones in the human retina. The peak wavelengths of L, M, and S cones occur in the ranges of 564–580 nm , 534–545 nm , and 420–440 nm nm, respectively, depending on the individual.
Distribution of rods and cones along a line passing through the fovea and the blind spot of a human eye [7] Most vertebrate photoreceptors are located in the retina. The distribution of rods and cones (and classes thereof) in the retina is called the retinal mosaic. Each human retina has approximately 6 million cones and 120 million rods. [8]
An ipRGC, shown here as a complied image of the retina from proximal inner nuclear layer to the ganglion cell layer with fluorescent labeling of melanopsin Spectral sensitivities of the photoreceptors in the human eye. [4] Compared to the rods and cones, the ipRGCs respond more sluggishly and signal the presence of light over the long term. [5]
The human eye contains three types of photoreceptors, rods, cones, and intrinsically photosensitive retinal ganglion cells (ipRGCs). Rods and cones are responsible for vision and connected to the visual cortex. ipRGCs are more connected to body clock functions and other parts of the brain but not the visual cortex.
"The 3T3 Neutral Red Uptake Phototoxicity Assay (3T3 NRU PT) can be utilized to identify the phototoxic effect of a test substance induced by the combination of test substance and light. The test compares the cytotoxic effect of a test substance when tested after the exposure, then tested in the absence of exposure to a non-cytotoxic dose of ...
While cones (which are responsible for color perception and detail) are activated in brighter light, the rods provide vision in low light, but with a loss of precision. Therefore, the graininess we perceive in the dark is a natural adaptation of our vision to photoreceptor limitations, not a sign of some abnormality.