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Ethanolamine-O-sulfate (EOS) is an ester of sulfuric acid and ethanolamine. EOS is a GABA transaminase inhibitor which prevents the metabolism of GABA. [2] It is used as a biochemical tool in studies involving GABA. EOS is also a diuretic [3] and an anticonvulsant. [4]
(2-[(4-Aminophenyl)sulfonyl]ethyl hydrogen sulfate) Possible variations result from further substituents on the aromatic ring - usually hydroxy, methyl or methoxy groups - or from the position of the amino relative to the vinyl sulfone group. In addition to the para-substituted compound, also meta- and orthosubstituted vinyl sulfone anilines ...
C 6 H 6 + H 2 SO 4 → C 6 H 5 SO 3 H + H 2 O. Sulfur trioxide or its protonated derivative is the actual electrophile in this electrophilic aromatic substitution. To drive the equilibrium, dehydrating agents such as thionyl chloride can be added: [2] C 6 H 6 + H 2 SO 4 + SOCl 2 → C 6 H 5 SO 3 H + SO 2 + 2 HCl. Historically, mercurous sulfate ...
The scheme depicts the mechanism for the Leuckart reaction using formamide as the reducing agent. Formamide first nucleophilically attacks the carbonyl carbon. The oxygen is protonated by abstracting hydrogen from the nitrogen atom, subsequently forming a water molecule that leaves, forming N-formyl derivative, which is resonance stabilized. [ 3 ]
Ethyl sulfate can be produced in a laboratory setting by reacting ethanol with sulfuric acid under a gentle boil, while keeping the reaction below 140 °C. The sulfuric acid must be added dropwise or the reaction must be actively cooled because the reaction itself is highly exothermic. CH 3 CH 2 OH + H 2 SO 4 → CH 3 CH 2 OSO 3 H + H 2 O
The acid chloride suffers attack by diazomethane with loss of HCl. The alpha-diazoketone (RC(O)CHN 2) product undergoes the metal-catalyzed Wolff rearrangement to form a ketene, which hydrates to the acid. [16] [17] [4] The rearrangement leaves untouched the stereochemistry at the carbon alpha to the acid chloride. [6]
Solid sodium 2-hydroxyethyl sulfonate is a colorless, free-flowing, non-hygroscopic solid, which dissolves readily in water and has good biodegradability. Due to the method of synthesis samples often contain traces of sodium sulfite or sodium hydrogen sulfite causing aqueous solution to possesses a mildly alkaline pH of about 10.
Triethylenetetramine (TETA and trien), also known as trientine when used medically, is an organic compound with the formula [CH 2 NHCH 2 CH 2 NH 2] 2. The pure free base is a colorless oily liquid, but, like many amines, older samples assume a yellowish color due to impurities resulting from air oxidation. It is soluble in polar solvents.