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JWH-018 is a full agonist of both the CB 1 and CB 2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB 1 and 2.94 ± 2.65 nM at CB 2. [6] JWH-018 has an EC 50 of 102 nM for human CB 1 receptors, and 133 nM for human CB 2 receptors. [16]
JWH-018 [5] Naphthoylindole: 9 ± 5: 2.9 ± 2.6: CB 2 (3.1x) JWH-019: Naphthoylindole: 9.8 ± 2: 5.55 ± 2: CB 2 (1.77x) JWH-020: Naphthoylindole: 128 ± 17: 205 ± 20: CB 1 (1.6x) JWH-030: Naphthoylpyrrole: 87 ± 3: 320 ± 127: CB 1 (3.7x) JWH-031: Naphthoylpyrrole: 399 ± 109: JWH-032: Naphthoylpyrrole >10000 >10000 — JWH-033 ...
JWH-018, JWH-073, CP 47,497 (and its homologues), and HU-210, as well as leonotis leonurus, have been all banned in Latvia since 2005. [135] After the first confirmed lethal case from the use of legal drugs in late 2013, parliament significantly increased the number of temporarily banned substances used in Spice and similar preparations.
JWH cannabinoids are those discovered by John W. Huffman and his team. Pages in category "JWH cannabinoids" The following 56 pages are in this category, out of 56 total.
FUB-JWH-018 (also known as FUB-018) is a naphthoylindole-based synthetic cannabinoid, representing a molecular hybrid of JWH-018 and AB-FUBICA or ADB-FUBICA. [1] [2]
JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. It is the N -hexyl homolog of the more common synthetic cannabinoid compound JWH-018 .
JWH-081 is an analgesic chemical from the naphthoylindole family, which acts as a cannabinoid agonist at both the CB 1 and CB 2 receptors. [3] With a K i of 1.2nM it is fairly selective for the CB 1 subtype, its affinity at this subtype is measured at approximately 10x the affinity at CB 2 (12.4nM). [ 4 ]
JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman.It is a methylated analogue of JWH-018.It has a K i of 0.69 nM at CB 1 and 1.2 nM at CB 2. [2]In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, California, that was laced with JWH-122.