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dbAMP: [75] Provides an online platform for exploring antimicrobial peptides with functional activities and physicochemical properties on transcriptome and proteome data. dbAMP is an online resource that addresses various topics such as annotations of antimicrobial peptides (AMPs) including sequence information, antimicrobial activities, post ...
AMDD otherwise known as Antimicrobial Drug Database is a biological database that seeks to consolidate antibacterial and antifungal drug information from a variety of sources such as PubChem, PubChem Bioassay, ZINC, ChemDB and DrugBank in order to advance the field of treatment of resistance microbes.
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The Comprehensive Antibiotic Resistance Database (CARD) is a biological database that collects and organizes reference information on antimicrobial resistance genes, proteins and phenotypes. [ 1 ] [ 2 ] The database covers all types of drug classes and resistance mechanisms and structures its data based on an ontology.
Bacitracin is a polypeptide antibiotic derived from a bacterium, Bacillus subtilis, and acts against bacteria through the inhibition of cell wall synthesis. [6] It does this by inhibiting the removal of phosphate from lipid compounds, thus deactivating its function to transport peptidoglycan; the main component of bacterial cell membranes, to the microbial cell wall.
Defensin mimetics, also called host defense peptide (HDP) mimetics, are completely synthetic, non-peptide, small molecule structures that mimic defensins in structure and activity. [51] Similar molecules, such as brilacidin , are being developed as antibiotics , [ 52 ] anti-inflammatories for oral mucositis , [ 53 ] [ 54 ] and antifungals ...
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The tool’s Bacterial Antimicrobial Resistance Reference Gene Database consists of up-to-date gene nomenclature, a set of hidden Markov models (HMMs), and a curated protein family hierarchy. The database contains over 627 AMR HMMs, 6,428 genes, and 682 mutations, placing this data in a hierarchical framework of gene families, symbols, and ...