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There is a substantial amount of empirical research on negative affect (NA) and its role in the tripartite model. For example, the Mood and Anxiety Symptom Questionnaire (MASQ) [ 10 ] was administered to a sample of college students and a sample of psychiatric patients.
The biology of depression is the attempt to identify a biochemical origin of depression, as opposed to theories that emphasize psychological or situational causes. Scientific studies have found that different brain areas show altered activity in humans with major depressive disorder (MDD) . [ 1 ]
The largest limitation of evolutionary explanations of depression, which include rank theory, is the lack of falsifiability. [9] While these theories provide "reasonably parsimonious" explanations, [10] they are not grounded in empirical research, which severely affects their real-world application.
The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.
Depression is a significant mental illness with physiological and psychological consequences, including sluggishness, diminished interest and pleasure, and disturbances in sleep and appetite. [1] It is predicted that by the year 2030, depression will be the number one cause of disability in the United States and other high-income countries. [2]
One reason depression is thought to be a pathology is that it causes so much psychic pain and distress. However, physical pain is also very distressful, yet it has an evolved function: to inform the organism that it is being damaged, to motivate it to withdraw from the source of damage, and to learn to avoid such damage-causing circumstances in the future.
Depression and Anxiety is a monthly peer-reviewed medical journal published by Wiley-Blackwell.It is an official journal of the Anxiety and Depression Association of America and covers research on depressive and anxiety disorders.
Depression is a mental state of low mood and aversion to activity. [3] It affects about 3.5% of the global population, or about 280 million people worldwide, as of 2020. [4] Depression affects a person's thoughts, behavior, feelings, and sense of well-being. [5]
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