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The tumor necrosis factor (TNF) superfamily is a protein superfamily of type II transmembrane proteins containing TNF homology domain and forming trimers. Members of this superfamily can be released from the cell membrane by extracellular proteolytic cleavage and function as a cytokine .
Tumor necrosis factor (TNF), formerly known as TNF-α, is a chemical messenger produced by the immune system that induces inflammation. [5] TNF is produced primarily by activated macrophages , and induces inflammation by binding to its receptors on other cells. [ 6 ]
The tumor necrosis factor receptor superfamily (TNFRSF) is a protein superfamily of cytokine receptors characterized by the ability to bind tumor necrosis factors (TNFs) via an extracellular cysteine-rich domain. [2] [3] With the exception of nerve growth factor (NGF), all TNFs are homologous to the archetypal TNF-alpha. [4]
Lymphotoxin-alpha (LT-α) formerly known as tumor necrosis factor-beta (TNF-β) [5] [6] is a protein that in humans is encoded by the LTA gene. [ 7 ] [ 8 ] Belonging to the hematopoietic cell line, LT-α exhibits anti-proliferative activity and causes the cellular destruction of tumor cell lines. [ 7 ]
27279 Ensembl ENSG00000006327 ENSMUSG00000023905 UniProt Q9NP84 Q9CR75 RefSeq (mRNA) NM_016639 NM_001161746 NM_013749 RefSeq (protein) NP_057723 NP_001155218 NP_038777 Location (UCSC) Chr 16: 3.02 – 3.02 Mb Chr 17: 23.89 – 23.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a ...
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/ TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
The protein encoded by this gene is a member of the tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate the transcription factor NF-κB, mediate apoptosis, and function as a regulator of inflammation.
CD137, a member of the tumor necrosis factor receptor family, is a type 1 transmembrane protein, expressed on surfaces of leukocytes and non-immune cells. [5] [6] Its alternative names are tumor necrosis factor receptor superfamily member 9 (TNFRSF9), 4-1BB, and induced by lymphocyte activation (ILA).