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Drugs used in diabetes treat types of diabetes mellitus by decreasing glucose levels in the blood. With the exception of insulin , most GLP-1 receptor agonists ( liraglutide , exenatide , and others), and pramlintide , all diabetes medications are administered orally and are thus called oral hypoglycemic agents or oral antihyperglycemic agents.
PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome , mainly for lowering triglycerides and blood sugar .
It is a first in class drug which acts as a dual PPAR agonist at the subtypes α (alpha) and γ (gamma) of the peroxisome proliferator-activated receptor (PPAR). Agonist action on PPARα lowers high blood triglycerides, and agonist action on PPARγ improves insulin resistance and consequently lowers blood sugar. [2]
One of the most common drugs used in T2D, metformin is the drug of choice to help patients lower their blood sugar levels. Metformin is an example of a class of medicine called biguanides. [ 34 ] The medication works by reducing the new creation of glucose from the liver and by reducing absorption of sugar from food. [ 34 ]
These drugs not only lower blood sugar but also increase urinary glucose excretion, which leads to reduced insulin levels and elevated ketone bodies in the body. Since ketones are known to be ...
Berberine has potential benefits for heart health, such as lowering triglycerides (fat in the blood), total and LDL cholesterol, and systolic blood pressure, says Dr. Lona Sandon, PhD, RDN, LD, a ...
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