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Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia, tics in Tourette syndrome, mania in bipolar disorder, delirium, agitation, acute psychosis, and hallucinations from alcohol withdrawal.
A 3.75-cm (1.5-inch), 21-gauge needle is generally used, but obese individuals may require a 6.5-cm (2.5-inch) needle to ensure that the drug is indeed injected intramuscularly and not subcutaneously. [6]
Neuroleptic malignant syndrome (NMS) is a rare [5] [6] but life-threatening reaction that can occur in response to antipsychotics (neuroleptic) or other drugs that block the effects of dopamine. [1] [7] Symptoms include high fever, confusion, rigid muscles, variable blood pressure, sweating, and fast heart rate. [1]
Haloperidol binds D 2, D 3 and D 4 with the highest affinity, but also binds D 1 and D 5. [1] [2] [3] Haloperidol also has a risk for QTc prolongation. [17] Fluphenazine binds D 2 and D 3 with the highest affinity but D 1 and D 5 as well [1] [2] Flupentixol binds D 1, D 2, D 3, and D 5 [2] and is also used as an antidepressant. [1] Fluspirilene ...
[42] [43] Furthermore, multiple sessions of WBV have failed to enhance mobility measures (i.e., the Timed Up and Go Test and 10-Meter Walking Test) in people with Parkinson's disease. [ 42 ] [ 43 ] A recent review deemed that the evidence of the effects of WBV training on sensorimotor and functional performance remains inconclusive.
Typical antipsychotics block the dopamine 2 receptor (D2) receptor, causing a tranquilizing effect. [5] It is thought that 60–80% of D2 receptors need to be occupied for antipsychotic effect. [ 5 ] For reference, the typical antipsychotic haloperidol tends to block about 80% of D2 receptors at doses ranging from 2 to 5 mg per day. [ 5 ]
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