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The disputed late-life mortality deceleration law states that death rates stop increasing exponentially at advanced ages and level off to the late-life mortality plateau. A consequence of this deceleration is that there would be no fixed upper limit to human longevity — no fixed number which separates possible and impossible values of lifespan.
Life history theory has provided new perspectives in understanding many aspects of human reproductive behavior, such as the relationship between poverty and fertility. [43] A number of statistical predictions have been confirmed by social data [ citation needed ] and there is a large body of scientific literature from studies in experimental ...
The theory is based on the idea that ageing occurs over time due to the damage of the DNA. As an example, studies of mammalian brain and muscle have shown that DNA repair capability is relatively high during early development when cells are dividing mitotically, but declines substantially as cells enter the post-mitotic state. [28] [29] [30]
Lastly, genetic and environmental factors, rather than reproductive patterns, may explain the variations in human lifespan. For example, studies have shown that poorer individuals, to whom nutritious food and medical care is less accessible, typically have higher birth rates and earlier primiparity. [49]
"The first 1000-year-old is probably only ~10 years younger than the first 150-year-old."–Aubrey de Grey, 2005 [1]. In the life extension movement, longevity escape velocity (LEV), actuarial escape velocity [2] or biological escape velocity [3] is a hypothetical situation in which one's remaining life expectancy (not life expectancy at birth) is extended longer than the time that is passing.
For sexually reproducing planaria: "the lifespan of individual planarian can be as long as 3 years, likely due to the ability of neoblasts to constantly replace aging cells". Whereas for asexually reproducing planaria: "individual animals in clonal lines of some planarian species replicating by fission have been maintained for over 15 years".
So far, empirical research from a life course perspective has not resulted in the development of a formal theory. [8] Glen Elder theorized the life course as based on five key principles: life-span development, human agency, historical time and geographic place, timing of decisions, and linked lives. As a concept, a life course is defined as "a ...
The longest documented human lifespan is 122 years 164 days, the case of Jeanne Calment, who according to records was born in 1875 and died in 1997, whereas the maximum lifespan of a wildtype mouse, commonly used as a model in research on aging, is about three years. [10]