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On treatment for male erectile dysfunction (ED), a review article by Tam et al. (2001) concluded: Although well-tolerated and safe, even when greatly exceeding the likely therapeutic range, it is obvious that the efficacy of [yohimbine] as monotherapy in the general ED population is likely to be modest.
Although proposed as a potential treatment for erectile dysfunction in humans, there are concerns about its safety or effectiveness. [2] [3] Side effects of using yohimbe, particularly in high doses, may include hypertension, increased heart rate, headache, nausea, tremors, and insomnia. [2]
The term erectile dysfunction does not encompass other erection-related disorders, such as priapism. Treatment of ED encompasses addressing the underlying causes, lifestyle modification, and addressing psychosocial issues. [4] In many instances, medication-based therapies are used, specifically PDE5 inhibitors like sildenafil. [13]
Endothelial dysfunction is a risk factor that is specifically associated with erectile dysfunction. [13] Past family medical history of sexual dysfunction disorders are also a risk factor for development. Sociocultural factors may also contribute to sexual problems, such as personal, religious, or cultural beliefs about sex.
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Yohimbine, an α 2 blocker derived from the bark of the Pausinystalia johimbe tree, has been tested to increase libido and treat erectile dysfunction. The proposed mechanism for yohimbine is blockade of the adrenergic receptors that are associated with neurotransmitters inhibition, including dopamine and nitric oxide , and thus aiding with ...
The name "herbal viagra" is taken from the brand name Viagra, under which drug company Pfizer sells sildenafil citrate, a drug used to treat erectile dysfunction. [3] Viagra has become a generic term for many people discussing drugs designed to treat erectile dysfunction, even those which do not contain sildenafil.
Dapoxetine, sold under the brand name Priligy among others, is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation (PE) in men ages 18 to 64 years old. [ 3 ] [ 4 ] [ 5 ] Dapoxetine works by inhibiting the serotonin transporter , increasing serotonin's action at the postsynaptic cleft, and as a ...
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