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The test was first introduced in 1956, using iodine-131 diodrast. [25] [26] Later developments included iodine-131, and then iodine-123, labelled ortho-Iodohippuric acid (OIH, marketed as Hippuran). [27] [28] 99m Tc-MAG3 has replaced 131 I-OIH because of better quality imaging regardless of the level of kidney function, [29] and lower radiation ...
Radioactive iodine (iodine-131) alone can potentially worsen thyrotoxicosis in the first few days after treatment. One side effect of treatment is an initial period of a few days of increased hyperthyroid symptoms. This occurs because when the radioactive iodine destroys the thyroid cells, they can release thyroid hormone into the blood stream.
In one study, researchers gave pregnant women between 100 and 200 microcuries (3.7 and 7.4 MBq) of iodine-131, and later performed abortions to study the women's embryos in an attempt to discover at what stage, and to what extent, radioactive iodine crosses the placental barrier. [67]
Toxic multinodular goiter can be treated with antithyroid medications such as propylthiouracil or methimazole, radioactive iodine, or with surgery. [5] Another treatment option is injection of ethanol into the nodules. [9] A Cochrane review compared treatments using recombinant human thyrotropin-aided radioactive iodine to radioactive iodine ...
enlisting doctors to administer radioactive iron to impoverished pregnant women [5] exposing U.S. soldiers and prisoners to high levels of radiation [4] irradiating the testicles of prisoners, which caused severe birth defects [4] exhuming bodies from graveyards to test them for radiation (without the consent of the families of the deceased) [6]
Hypothyroidism is common in pregnancy with an estimated prevalence of 2-3% and 0.3-0.5% for subclinical and overt hypothyroidism respectively. [8] Endemic iodine deficiency accounts for most hypothyroidism in pregnant women worldwide while chronic autoimmune thyroiditis is the most common cause of hypothyroidism in iodine sufficient parts of the world.
Around the world, the most common cause of congenital hypothyroidism is iodine deficiency, but in most of the developed world and areas of adequate environmental iodine, cases are due to a combination of known and unknown causes. Most commonly there is a defect of development of the thyroid gland itself, resulting in an absent (athyreosis) or ...
A radioimmunoassay (RIA) is an immunoassay that uses radiolabeled molecules in a stepwise formation of immune complexes.A RIA is a very sensitive in vitro assay technique used to measure concentrations of substances, usually measuring antigen concentrations (for example, hormone levels in blood) by use of antibodies.