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Testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days when used as a depot intramuscular injection. [2] It requires frequent administration of approximately once per week, and large fluctuations in testosterone levels result with it, with levels initially being elevated and supraphysiological. [2]
As oil solutions by intramuscular injection, the elimination half-lives of testosterone esters are 0.8 days for testosterone propionate, 4.5 days for testosterone enanthate, 20.9 days (in tea seed oil) and 33.9 days (in caster oil) for testosterone undecanoate, and 29.5 days for testosterone buciclate.
Pharmacokinetics of testosterone esters Testosterone ester Form Route T max Tooltip Time to peak levels t 1/2 Tooltip Elimination half-life MRT Tooltip Mean residence time; Testosterone undecanoate: Oil-filled capsules: Oral? 1.6 hours: 3.7 hours Testosterone propionate: Oil solution: Intramuscular injection? 0.8 days: 1.5 days Testosterone ...
t 1/2 Tooltip Elimination half-life MRT Tooltip Mean residence time; Testosterone undecanoate: Oil-filled capsules: Oral? 1.6 hours: 3.7 hours Testosterone propionate: Oil solution: Intramuscular injection? 0.8 days: 1.5 days Testosterone enanthate: Castor oil solution: Intramuscular injection: 10 days: 4.5 days: 8.5 days Testosterone ...
Testosterone undecanoate: Castor oil solution: Intramuscular injection: 11.4 days: 33.9 days: 36.0 days Testosterone buciclate a: Aqueous suspension: Intramuscular injection: 25.8 days: 29.5 days: 60.0 days Notes: Testosterone cypionate has similar pharmacokinetics to Testosterone enanthate. Footnotes: a = Never marketed. Sources: [1] [2] [3]
The different testosterone esters provide for different elimination half-lives in the body. Esterification of testosterone provides for a sustained but non-linear release of testosterone hormone from the injection depot into the circulation. Sustanon 100 is administered once every 2 weeks and Sustanon 250 is administered once every 3 to 4 weeks ...
[4] [3] As such, testosterone cypionate and testosterone enanthate are considered to be "functionally interchangeable" as medications. [4] For reference, testosterone enanthate has an elimination half-life of 4.5 days and a mean residence time of 8.5 days and requires frequent administration of approximately once per week. [21]
Testosterone is a medication and naturally occurring steroid hormone. [9] It is used to treat male hypogonadism, gender dysphoria, and certain types of breast cancer. [9] [10] It may also be used to increase athletic ability in the form of doping. [9]