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Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. [1] A 1984 study found a weight loss of 7.5 kg on average in 24 weeks, as compared to 4.4 kg under placebo. [4] It sold modestly until the 1990s, when it was combined with phentermine and heavily marketed.
HPG regulation in males, with the inhibin/activin system playing a similar role on GnRH-producing cells. The hypothalamus is located in the brain and secretes GnRH. [1] GnRH travels down the anterior portion of the pituitary via the hypophyseal portal system and binds to receptors on the secretory cells of the adenohypophysis. [2]
Orexin (/ ɒ ˈ r ɛ k s ɪ n /), also known as hypocretin, is a neuropeptide that regulates arousal, wakefulness, and appetite. [5] It exists in the forms of orexin-A and orexin-B.The most common form of narcolepsy, type 1, in which the individual experiences brief losses of muscle tone ("drop attacks" or cataplexy), is caused by a lack of orexin in the brain due to destruction of the cells ...
Vitamin B12, also known as cobalamin, isn’t just a popular supplement marketed to help people lose weight— it’s an essential water-soluble vitamin necessary for brain function, heart health ...
Doctors evaluate weight loss claims. A. Pawlowski. September 19, 2024 at 9:12 PM. Weight loss with Ozempic or Wegovy can be effective, but expensive. Enter so-called GLP-1 supplements that have ...
Hypothalamic disease is a disorder presenting primarily in the hypothalamus, which may be caused by damage resulting from malnutrition, including anorexia and bulimia eating disorders, [1][2] genetic disorders, radiation, surgery, head trauma, [3] lesion, [1] tumour or other physical injury to the hypothalamus.
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