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Target validation normally requires the determination that the target is expressed in the disease-relevant cells/tissues, [6] it can be directly modulated by a drug or drug-like molecule with adequate potency in biochemical assay, [7] and that target modulation in cell and/or animal models ameliorates the relevant disease phenotype. [8]
Current Cancer Drug Targets is a peer-reviewed medical journal published by Bentham Science Publishers.The editor-in-chief is Ruiwen Zhang (UH Drug Discovery Institute). The journal covers research on contemporary molecular drug targets involved in cancer, including medicinal chemistry, pharmacology, molecular biology, genomics, and biochemistry.
This version contained 1424 approved small molecule drugs and 132 biotech drugs as well as >4000 unique drug targets. Version 3.0 also included drug transporter data, drug pathway data, drug pricing, patent and manufacturing data as well as data on >5000 experimental drugs.
TDR Targets: Tropical Disease Research Trypanosomatics Laboratory drugs and targets "TDR Targets". 2,000,000 TTD Therapeutic Targets Database Zhejiang University: drugs and targets SMILES InChI CAS PubChem "TTD". 37,316 T3DB Toxin and Toxin-Target Database Toxic Exposome Database. University of Alberta: toxins and toxin targets T3D "T3DB ...
Potential drug targets are not necessarily disease causing but must by definition be disease modifying. [8] An alternative means of identifying new drug targets is forward pharmacology based on phenotypic screening to identify "orphan" ligands [9] whose targets are subsequently identified through target deconvolution. [10] [11] [12]
Drug Manufacturer Indication Avacincaptad pegol: To treat geographic atrophy secondary to age-related macular degeneration [4] Cipaglucosidase alfa: To treat late-onset Pompe disease with miglustat [4] Dabrafenib: Dostarlimab: Eflornithine: Elranatamab: To treat relapsed or refractory multiple myeloma after at least four lines of therapy [4 ...
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In an estimate from 2011, 435 human genome products were identified as therapeutic drug targets of FDA-approved drugs. [21] "Established targets" are those for which there is a good scientific understanding, supported by a lengthy publication history, of both how the target functions in normal physiology and how it is involved in human ...