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Danicopan, sold under the brand name Voydeya, is a medication used for the treatment of paroxysmal nocturnal hemoglobinuria. It is a complement inhibitor which reversibly binds to factor D to prevent alternative pathway-mediated hemolysis and deposition of complement C3 proteins on red blood cells. The most common side effects include fever, headache, increased levels of liver enzymes (a sign ...
The Ham test is a blood test used in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH). Patient red blood cells (RBCs) are placed in mild acid; a positive result (increased RBC fragility) indicates PNH or congenital dyserythropoietic anemia. [1] [2] This is now an obsolete test for diagnosing PNH due to its low sensitivity and ...
The sucrose lysis test is a diagnostic laboratory test used for diagnosing paroxysmal nocturnal hemoglobinuria (PNH), as well as for hypoplastic anemias and any hemolytic anemia with an unclear cause. [1] The test works by using sucrose, which creates a low ionic strength environment that allows complement to bind to red blood cells. [1]
Extended matching items/questions (EMI or EMQ) are a written examination format similar to multiple choice questions but with one key difference, that they test knowledge in a far more applied, in-depth, sense. It is often used in medical education and other healthcare subject areas to test diagnostic reasoning.
Hematology (spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. [ 1 ] [ 2 ] It involves treating diseases that affect the production of blood and its components, such as blood cells , hemoglobin , blood proteins , bone marrow ...
Other blood group incompatibility (RhC, Rhe, Kid, Duffy, MN, P and others) Drug induced immune mediated hemolytic anemia Penicillin (high dose) Methyldopa; Hemoglobinopathies (where these is an unstable or crystalline hemoglobin) Paroxysmal nocturnal hemoglobinuria (rare acquired clonal disorder of red blood cell surface proteins)
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This is an incomplete list, which may never be able to satisfy certain standards for completion.. There are many conditions of or affecting the human hematologic system—the biological system that includes plasma, platelets, leukocytes, and erythrocytes, the major components of blood and the bone marrow.
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