Search results
Results from the WOW.Com Content Network
A retrovirus is a type of virus that inserts a DNA copy of its RNA genome into the DNA of a host cell that it invades, thus changing the genome of that cell. [2] After invading a host cell's cytoplasm, the virus uses its own reverse transcriptase enzyme to produce DNA from its RNA genome, the reverse of the usual pattern, thus retro (backward).
Rarely, retroviral integration may occur in a germline cell that goes on to develop into a viable organism. This organism will carry the inserted retroviral genome as an integral part of its own genome—an "endogenous" retrovirus (ERV) that may be inherited by its offspring as a novel allele. Many ERVs have persisted in the genome of their ...
Using the consensus sequence for retroviral pol and "panretro" RT-PCR extensions from the pol region of MSRV (retroviral RNA), the discovery of a HERV with gag, pol, and env was made possible. [11] The primer binding site (PBS) of this HERV was discovered to be similar to avian retroviral PBSs, which use tRNATRP.
The double stranded DNA is highly stable and easily integrated into a host genome. A few examples of the virus are Moloney murine leukemia virus, xenotropic MuLB-related virus, feline leukemia virus, and feline sarcoma virus. [6] [7] [8] Gammaretroviruses are very popular retroviral vectors in laboratory studies.
For example, some protect against infection with related viruses. [ 10 ] [ 11 ] In some mammal groups, including higher primates , retroviral envelope proteins have been exapted to produce a protein that is expressed in the placental syncytiotrophoblast , and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the ...
For example, a model of mouse hemophilia is corrected by expressing wild-type platelet-factor VIII, the gene that is mutated in human hemophilia. [11] Lentiviral infection has advantages over other gene-therapy methods including high-efficiency infection of dividing and non-dividing cells, long-term stable expression of a transgene , and low ...
Koala retrovirus (KoRV) [1] is a retrovirus that is present in many populations of koalas.It has been implicated as the agent of koala immune deficiency syndrome (KIDS), an AIDS-like immunodeficiency that leaves infected koalas more susceptible to infectious disease and cancers.
Feline leukemia virus (FeLV) is a retrovirus that infects cats.FeLV can be transmitted from infected cats when the transfer of saliva or nasal secretions is involved. If not defeated by the animal's immune system, the virus weakens the cat's immune system, which can lead to diseases which can be lethal.