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Equally important, better HLA matching reduces the number of antibodies that a transplant recipient will create making it easier to get a second, third or fourth transplant. [41] This issue is critical for young transplant recipients who have a life expectancy that is longer than the expected graft survival (i.e. how long a transplanted kidney ...
Kidney transplant requirements vary from program to program and country to country. Many programs place limits on age (e.g. the person must be under a certain age to enter the waiting list) and require that one must be in good health (aside from kidney disease).
During tissue typing, a number of HLA genes should be typed in both the donor and recipient, including HLA Class I A, B, and C genes, as well as HLA Class II DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, DPA1, and DPB1 genes. [6] HLA typing is made more difficult by the fact that the HLA region is the most genetically variable region in the human genome. [7]
There is a shortage of organs available for donation with many patients waiting on the transplant list for a donation match. About 20 patients die each day waiting for an organ on the transplant list. [43] When an organ donor does arise, the transplant governing bodies must determine who receives the organ.
[1] [2] More than one-third of potential living kidney donors who want to donate their kidney to a friend or family member cannot because of blood type or antibody incompatibility. [3] Historically, these donors would be turned away and the patient would lose the opportunity to receive a life-saving kidney transplant. KPD overcomes donor ...
54-1327878 [2]: Legal status: 501(c)(3) nonprofit organization [2] Headquarters: Richmond, Virginia, U.S. [3]: Coordinates: Services: Manages the U.S. organ transplant system under contract with the federal government by bringing together transplant and organ procurement professionals and volunteers in order to make life-saving organ transplants possible.
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Optimal kidney exchange (OKE) is an optimization problem faced by programs for kidney paired donations (also called Kidney Exchange Programs). Such programs have large databases of patient-donor pairs, where the donor is willing to donate a kidney in order to help the patient, but cannot do so due to medical incompatibility.
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