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3351 15551 Ensembl ENSG00000135312 ENSMUSG00000049511 UniProt P28222 P28334 RefSeq (mRNA) NM_000863 NM_010482 RefSeq (protein) NP_000854 NP_034612 Location (UCSC) Chr 6: 77.46 – 77.46 Mb Chr 9: 81.51 – 81.52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse 5-hydroxytryptamine receptor 1B also known as the 5-HT 1B receptor is a protein that in humans is encoded by the HTR1B gene ...
The 5-HT 1B receptor as an example of a metabotropic serotonin receptor. Its crystallographic structure in ribbon representation. 5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems.
The 5-HT 1 receptors are a subfamily of the 5-HT serotonin receptors that bind to the endogenous neurotransmitter serotonin (also known as 5-hydroxytryptamine, or 5-HT). [1] The 5-HT 1 subfamily consists of five G protein-coupled receptors (GPCRs) that share 40% to 63% overall sequence homology, including 5-HT 1A, 5-HT 1B, 5-HT 1D, 5-HT 1E, and 5-HT 1F. [2]
15550 Ensembl ENSG00000178394 ENSMUSG00000021721 UniProt P08908 Q64264 RefSeq (mRNA) NM_000524 NM_008308 RefSeq (protein) NP_000515 NP_032334 Location (UCSC) Chr 5: 63.96 – 63.96 Mb Chr 13: 105.58 – 105.58 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse The serotonin 1A receptor (or 5-HT 1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin ...
5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it. [ 5 ] 5-HT 1D acts on the central nervous system , and affects locomotion and anxiety .
GR-55562 is a selective serotonin 5-HT 1B and 5-HT 1D receptor antagonist. [1] It is one of several selective serotonin 5-HT 1B receptor antagonists used in scientific research. [2] [3] The drug is a silent antagonist of the serotonin 5-HT 1B receptor, unlike the related agent GR-127935.
CP-94253 is a drug which acts as a potent and selective serotonin 5-HT 1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT 1D and 5-HT 1A receptors. [1] It has a range of behavioral effects, based on animal testing.
5-HT 1D receptor agonists are pharmaceutical drugs for the treatment of migraine. They include: Triptans (which additionally act as 5-HT 1B receptor agonists) Ergotamine (which also has other mechanisms of action) Dihydroergotamine, a derivative of the former; Alniditan