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Micrograph of necrotizing fasciitis, showing necrosis (center of image) of the dense connective tissue, i.e. fascia, interposed between fat lobules (top-right and bottom-left of image), H&E stain Early diagnosis is difficult, as the disease often looks early on like a simple superficial skin infection . [ 4 ]
Avascular necrosis (AVN), also called osteonecrosis or bone infarction, is death of bone tissue due to interruption of the blood supply. [1] Early on, there may be no symptoms. [ 1 ] Gradually joint pain may develop, which may limit the person's ability to move. [ 1 ]
Coagulative necrosis occurs primarily in tissues such as the kidney, heart and adrenal glands. [6] Severe ischemia most commonly causes necrosis of this form. [8] Liquefactive necrosis (or colliquative necrosis), in contrast to coagulative necrosis, is characterized by the digestion of dead cells to form a viscous liquid mass. [7]
Initial symptoms of Fournier gangrene include swelling or sudden pain in the scrotum, fever, pallor, and generalized weakness. It is characterized by pain that extends beyond the border of the demarcated erythema. [2] Most cases present mildly, but can progress in hours.
Genital ulcerations, uveitis, oral aphthous ulcers, and skin lesions are the main symptoms. [20] Cogan's syndrome (CS) is an uncommon type of autoimmune systemic vasculitis that causes inflammation inside the eyes and malfunctions the vestibulo-auditory system, usually resulting in neurosensory deafness but also tinnitus and vertigo. [21]
Gangrenous necrosis: Dry gangrene affecting the toes as a result of peripheral artery disease: Specialty: Infectious disease, surgery, podiatry: Symptoms: Change in skin color to red or black, numbness, pain, skin breakdown, coolness [1] Complications: Sepsis, amputation [1] [2] Types: Dry, wet, gas, internal, necrotizing fasciitis [3] Risk factors
Acne necrotica presents with a primary lesion that is a pruritic or painful erythematous follicular-based papule that develops central necrosis and crusting and heals with a varioliform scar. [ 1 ] : 650 [ 2 ] : 761
Various diagnostic methods can be employed in the diagnosis of Gas gangrene. Due to low incidence of myonecrosis it is an easy-to-overlook diagnosis. As bacterial infections mostly exhibit the same symptoms, early diagnosis of gas gangrene rarely occurs. The ambiguous symptoms only contribute to a poorer prognosis. Diagnostic methods include: [15]