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Cardiac fibrosis commonly refers to the excess deposition of extracellular matrix in the cardiac muscle, but the term may also refer to an abnormal thickening of the heart valves due to inappropriate proliferation of cardiac fibroblasts. [1] Fibrotic cardiac muscle is stiffer and less compliant and is seen in the progression to heart failure.
Hypertrophic cardiomyopathy (HCM, or HOCM when obstructive) is a condition in which muscle tissues of the heart become thickened without an obvious cause. [8] The parts of the heart most commonly affected are the interventricular septum and the ventricles. [10]
Cardiomyopathy is a group of primary diseases of the heart muscle. [1] Early on there may be few or no symptoms. [1] As the disease worsens, shortness of breath, feeling tired, and swelling of the legs may occur, due to the onset of heart failure. [1]
A myocardial infarction, also known as a heart attack, often result in the formation of fibrosis. [2] A myocardial infarction is an ischemic event, or a restriction of blood flow to body tissue, such as by atherothrombosis. [4] Without blood flow to the myocardium, it is deprived of oxygen, causing tissue death and irreversible damage. [5]
Coronary ischemia, myocardial ischemia, [1] or cardiac ischemia, [2] is a medical term for abnormally reduced blood flow in the coronary circulation through the coronary arteries. [3] Coronary ischemia is linked to heart disease , and heart attacks . [ 4 ]
Increased arterial stiffness is associated with an increased risk of cardiovascular events such as myocardial infarction, hypertension, heart failure, and stroke. [ 3 ] [ 4 ] [ 5 ] The World Health Organization identified cardiovascular disease as the leading cause of death globally in 2019.
Chemotherapy can treat amyloidosis if it is related to immunoglobulins. [4] Liver transplant can treat amyloidosis if it is related to familial transthyretin. [4]Acoramidis (Attruby) was approved for medical use in the United States in November 2024, to treat adults with cardiomyopathy of wild-type or variant (hereditary) transthyretin-mediated amyloidosis (ATTR-CM) to reduce death and ...
Information card published by the National Heart, Lung, and Blood Institute urging people with symptoms of angina to call the emergency medical services.. Because of the relationship between the duration of myocardial ischemia and the extent of damage to heart muscle, public health services encourage people experiencing possible acute coronary syndrome symptoms or those around them to ...
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