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A particular interest in oat β-glucan arose after a cholesterol lowering effect from oat bran reported in 1981. [2] In 1997, the FDA approved of a claim that intake of at least 3.0 g of β-glucan from oats per day decreased absorption of dietary cholesterol and reduced the risk of coronary heart disease. The approved health claim was later ...
A 2021 meta-analysis of clinical trials concluded that oat beta-glucan with molecular weights greater than 300 kg/mol reduced incremental area-under-the-curve by 23%, peak blood glucose by 28%, and insulin by 22% in a dose-responsive fashion, with similar results in participants with or without diabetes. [24]
As a rich source of dietary fiber (10 grams per 100 gram serving), whole oats supply beta-glucan (4 grams per 100 gram serving; table), a soluble fiber with cholesterol-lowering effects. [ 3 ] [ 6 ] [ 7 ]
In pharmacology, the international unit (IU) is a unit of measurement for the effect or biological activity of a substance, for the purpose of easier comparison across similar forms of substances. International units are used to quantify vitamins and biologics ( hormones , some medications , vaccines , blood products and similar biologically ...
A glucan is a polysaccharide derived from D-glucose, [1] linked by glycosidic bonds. Glucans are noted in two forms: alpha glucans and beta glucans. Many beta-glucans are medically important. They represent a drug target for antifungal medications of the echinocandin class.
According to Health Canada and the US Food and Drug Administration, consuming at least 3 grams per day of barley beta-glucan can lower levels of blood cholesterol, a risk factor for cardiovascular diseases. [75] [76] Eating whole-grain barley, a high-fibre grain, improves regulation of blood sugar (i.e., reduces blood glucose response to a meal ...
β-1,3-glucanase, an enzyme in plants that breaks down β-1,3-glucans such as callose or curdlan; β-1,6 glucanase, an enzyme that breaks down β-1,6-glucans; Cellulase, an enzyme that perform the hydrolysis of 1,4-beta-D-glycosidic linkages in cellulose, lichenin and cereal β-D-glucans. [2] Xyloglucan-specific endo-beta-1,4-glucanase
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