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Following FDA approval in 1970, ketamine anesthesia was first given to American soldiers during the Vietnam War. [142] The discovery of antidepressive action of ketamine in 2000 [143] has been described as the single most important advance in the treatment of depression in more than 50 years.
A slightly different version of ketamine, called esketamine or Spravato, was approved by the FDA in 2019 for treatment-resistant depression. Esketamine is given as a nasal spray and must be ...
Ketamine has been demonstrated to produce lasting antidepressant effects after administration in a clinical setting. In 2019, esketamine, an NMDA antagonist enantiomer of ketamine, was approved for use as an antidepressant in the United States. [17] In 2022, Auvelity was approved by the FDA for the treatment of depression.
After the publication of the NIH-run antidepressant clinical trial, clinics began opening in which the intravenous ketamine is given for depression. [5] [6] This practice is an off label use of IV ketamine in the United States, though the intranasal version of esketamine has been approved by the FDA for treatment of depression [5] [7] In 2015 there were about 60 such clinics in the US; the ...
An FDA-approved anesthetic, ketamine has been recognized as a fast-acting antidepressant drug for decades. The FDA officially approved esketamine, or ketamine nasal spray, for depression in 2019.
Ketamine is generally safe when taken under medical supervision, experts said, ... given through a nasal spray, was approved in 2019 by the FDA for treatment-resistant depression.
The US Food and Drug Administration (FDA) first approved the use of intranasal esketamine —an enantiomer of ketamine—for the use of ketamine-derived therapy for treatment-resistant depression, in 2019. [11]
What is ketamine approved to treat? It's been approved by the U.S. Food and Drug Administration, ... Ketamine is only FDA-approved for use as a nasal spray in treatment-resistant depression.