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Vascular risk factors can result in dysregulation of the neurovascular unit and hypoxia. Destruction of the organization of the blood–brain barrier, decreased cerebral blood flow, and the establishment of an inflammatory context often result in neuronal damage since these factors promote the aggregation of β-amyloid peptide in the brain. [37]
The maturation of blood vessels in the brain is a critical process that occurs postnatally. [6] It involves the acquisition of key barrier and contractile properties essential for brain function. During the early postnatal phase, endothelial cells (ECs) and vascular smooth muscle cells (VSMCs) undergo significant molecular and functional changes.
The human brain is the central organ of the nervous system, and with the spinal cord, comprises the central nervous system. It consists of the cerebrum, the brainstem and the cerebellum. The brain controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sensory nervous system ...
In vertebrates, the circulatory system is a system of organs that includes the heart, blood vessels, and blood which is circulated throughout the body. [1] [2] It includes the cardiovascular system, or vascular system, that consists of the heart and blood vessels (from Greek kardia meaning heart, and Latin vascula meaning vessels).
The cerebral arteries describe three main pairs of arteries and their branches, which perfuse the cerebrum of the brain. The three main arteries are the: Anterior cerebral artery (ACA), which supplies blood to the medial portion of the brain, including the superior parts of the frontal and anterior parietal lobes [1]
When watershed stroke occurs in the brain, it produces unique focal neurologic symptoms that aid clinicians in diagnosis and localization. For example, a cerebral watershed area is situated in the dorsal prefrontal cortex; when it is affected on the left side, this can lead to transcortical motor aphasia .
The arteries of the base of the brain. Superior cerebellar artery labeled near center. The temporal pole of the cerebrum and a portion of the cerebellar hemisphere have been removed on the right side (left half of diagram). Inferior aspect (viewed from below). The superior cerebellar artery supplies deep parts and superior parts of the cerebellum.
The pontine arteries are a number of small arteries which come off at right angles from either side of the basilar artery and supply the pons and adjacent parts of the brain. The pontine arteries include the paramedian arteries, the short circumferential, and the long circumferential arteries. [1] [a]