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The inhibition of miR-132 is a valid strategy in the prevention of heart failure progression in hypertrophic heart disease. [16] CDR132L is the first-in-class synthetic antisense oligonucleotide inhibitor targeting miR-132, developed by Cardior Pharmaceuticals in the framework of the therapeutic strategy to bind abnormal levels of miR-132 to ...
Pre-miRNA instead of Pri-miRNA in the first point of mechanism. Diagram of microRNA (miRNA) action with mRNA Examples of miRNA stem-loops, with the mature miRNAs shown in red. Micro ribonucleic acid (microRNA, miRNA, μRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. [1]
[2] [3] MiR-1 is known to play an important role in heart diseases such as hypertrophy, myocardial infarction, and arrhythmias. [4] [5] [6] Studies have shown that MiR-1 is an important regulator of heart adaption after ischemia or ischaemic stress and it is upregulated in the remote myocardium of patients with myocardial infarction. [7]
Prolong ischemia will eventually kill the cells and the destruction of cardiac cells leads to tissue death, which can lead to heart failure. Delivery of miRNA-210 to an ischemic heart improves heart function, possibly by promoting the release of angiogenic factors like interleukin-1α (IL-1α), tumor necrosis factor-α (TNF-α) and leptin, as ...
406947 n/a Ensembl ENSG00000283904 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 25.57 – 25.57 Mb n/a PubMed search n/a Wikidata View/Edit Human MiR-155 is a microRNA that in humans is encoded by the MIR155 host gene or MIR155HG. MiR-155 plays a role in various physiological and pathological processes. [7] [8] [9] Exogenous molecular control in ...
mir-143 is thought to play an important role in cardiac morphogenesis. mir–143 was found to be the most enriched miRNA in mouse embryonic stem cells that were differentiating into cardiac progenitor cells. [2] It is a direct transcriptional target of serum response factor, myocardin and nkx2-5. [2]
Postnatal heart development sees the upregulation of multiple miR-15 family members. In particular, miR-195, when found at higher levels than normal in the developing heart, has been identified as a factor that may cause heart abnormalities in newborns. [1]
Each member of miR-125 family has two different variants of mature miRNAs - 5p and 3p. Both variants originate from the same pre-miRNA. MiR-125-5p variant generally shows higher expression compared to miR-125-3p. [6] In humans, miR-125 family is composed of three homologs: hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. [7]