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In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale. The hepatic lobule is a building block of the liver tissue , consisting of portal triads, hepatocytes arranged in linear cords between a capillary network, and a central vein .
A Babylonian clay model of a sheep's liver dated to the Middle Bronze Age is preserved in the British Museum. [2] The Piacenza liver parallels the Babylonian artifact by representing the major anatomical features of the liver (the gall bladder, caudate lobe and posterior vena cava) as sculpted protrusions.
A liver segment is one of eight segments of the liver as described in the widely used Couinaud classification (named after Claude Couinaud) in the anatomy of the liver. This system divides the lobes of the liver into eight segments based on a transverse plane through the bifurcation of the main portal vein , [ 1 ] arranged in a clockwise manner ...
At birth, the liver comprises roughly 4% of body weight and weighs on average about 120 g (4 oz). Over the course of further development, it will increase to 1.4–1.6 kg (3.1–3.5 lb) but will only take up 2.5–3.5% of body weight. [40] Hepatosomatic index (HSI) is the ratio of liver weight to body weight. [41]
The falciform ligament, visible on the front of the liver, makes a superficial division of the right and left lobes of the liver. From the underside, the two additional lobes are located on the right lobe. [2] A line can be imagined running from the left of the vena cava and all the way forward to divide the liver and gallbladder into two ...
The surfaces of the phantom are defined by a large amount of polygonal meshes, most commonly triangles. The polygonal mesh has three remarkable advantages in developing whole-body phantoms. Firstly, mesh surfaces depicting human anatomy can be conveniently obtained from real patient images or commercial human anatomy mesh models.
The bare area of the liver is found on the posterosuperior surface of the right lobe of the liver. [1] This lies close to the thoracic diaphragm. It is the only part of the liver that has no peritoneal covering. [1] [2] It lies between the two layers of the coronary ligament, as well as the right triangular ligament. [1]
In vitro model systems based on hepatocytes have been of great help to better understand the role of hepatocytes in (patho)physiological processes of the liver. In addition, pharmaceutical industry has heavily relied on the use of hepatocytes in suspension or culture to explore mechanisms of drug metabolism and even predict in vivo drug metabolism.
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