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2. Apixaban - Wikipedia

   en.wikipedia.org/wiki/Apixaban

   Apixaban is recommended by the National Institute for Health and Clinical Excellence for the prevention of stroke and systemic embolism in people with non-valvular atrial fibrillation and at least one of the following risk factors: prior stroke or transient ischemic attack, age 75 years or older, diabetes, or symptomatic heart failure.

3. Direct factor Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Direct_factor_Xa_inhibitors

   Side effects may include bleeding, most commonly from the nose, gastrointestinal tract (GI) or genitourinary system. [2] Compared to the risk of bleeding with warfarin use, direct factor Xa inhibitors have a higher risk of GI bleeding, but lower risk of bleeding in the brain. [2]

4. Daily low-dose aspirin has its benefits — and risks. Here's ...

   www.aol.com/lifestyle/aspirin-every-day-why-not...

   That was followed by a 2022 recommendation from the U.S. Preventive Services Task Force (USPSTF) stressing that people ages 60 or older should not take a daily baby aspirin for heart health ...

5. Discovery and development of direct Xa inhibitors - Wikipedia

   en.wikipedia.org/wiki/Discovery_and_development...

   The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...

6. Many older adults are still taking daily aspirin, even though ...

   www.aol.com/news/many-older-adults-still-taking...

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7. If you take aspirin daily, you could raise your risk of this ...

   www.aol.com/aspirin-daily-could-raise-risk...

   More than 40% of adults aged 60 and over take the pill to lower the risk of blood clots, but it’s a recommendation that many doctors have cut back on making recently.

8. Many Older Adults Take Daily Aspirin to Cut Cardiovascular ...

   www.aol.com/lifestyle/many-older-adults-daily...

   Many Americans 60 years and older still take daily aspirin to help prevent cardiovascular disease, even though it can pose significant health risks.

9. Direct thrombin inhibitor - Wikipedia

   en.wikipedia.org/wiki/Direct_thrombin_inhibitor

   Thrombin demonstrates a high level of allosteric regulation. [2] Allosterism in thrombin is regulated by the exosites 1 and 2 and the sodium binding site. A recent patent review has shown that the general consensus among researchers is that allosteric inhibitors may provide a more regulatable anticoagulant. [3]