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Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 μg (0.000532%), by calculation), phosphate buffers [8] Meningococcal vaccine Lactose, thimerosal (multi-dose vial only) Meningococcal vaccine Amino acids, formaldehyde, yeast extract MMR vaccine
There are different types of vials such as a single dose vial and multi-dose vials often used for medications. The single dose vial is only used once whereas a multi-dose vial can be used more than once. The CDC sets specific guidelines on multi-dose vials.
CDC Vaccine Information Statement for MMR Vaccine from April 2012. According to the 1993 amended National Childhood Vaccine Injury Act (NCVIA), a VIS must contain at least the following four components: (1) a description of the benefits of the given vaccine, (2) a description of its risks, (3) information about the National Vaccine Injury Compensation Program (VICP), and (4) other relevant ...
Thimerosal is used in these multi-dose vials to prevent contamination from multiple preparations. Contamination of the vaccine could cause serious infection. In a .5mL dose (which is in a single flu shot), there is 25 μg (micrograms) of mercury. This is 0.01% of the dose. [40] Single dose vials do not contain thimerosal.
ACIP statements are official federal recommendations for the use of vaccines and immune globulins in the U.S., and are published by the CDC. ACIP reports directly to the CDC director, although its management and support services are provided by CDC's National Center for Immunization and Respiratory Diseases. [1]
This is also the case for influenza vaccines in the US that come in single-dose vials or prefilled syringes. Some influenza vaccines are also available as a multi-dose vial, and in that form contain thiomersal (24.5 micrograms of mercury). [30] Phenol 0.25% v/v is used in Pneumovax 23, a pneumococcal polysaccharide vaccine, and in the smallpox ...
AD5-nCOV, trade-named Convidecia, is a single-dose [2] viral vector vaccine for COVID-19 that is also used as an inhaled booster. It was developed by CanSino Biologics , with Phase III trials conducted in Argentina , [ 3 ] Chile , [ 4 ] Mexico , [ 5 ] Pakistan , [ 6 ] Russia , [ 7 ] and Saudi Arabia [ 8 ] with 40,000 participants.
[22] [23] They asked vaccine makers to remove thiomersal from vaccines as quickly as possible as a precautionary measure, and it was rapidly phased out of most US and EU vaccines, [24] [25] but is still used in multi-dose vials of flu vaccines in the U.S. [26] [27] No vaccines in the European Union currently contain thiomersal as a preservative ...