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Enquiry into the evolution of ageing, or aging, aims to explain why a detrimental process such as ageing would evolve, and why there is so much variability in the lifespans of organisms. The classical theories of evolution (mutation accumulation, antagonistic pleiotropy, and disposable soma) [1][2][3] suggest that environmental factors, such as ...
Eliezer Masliah is a neuroscientist and medical researcher whose work concentrates on the biology of aging and Alzheimer's disease in particular. [1] He received his medical degree in 1982 from the National Autonomous University of Mexico. [2] [3] He was appointed head of the U.S. National Institute on Aging's Division of Neuroscience in 2016. [4]
Biogerontology is the sub-field of gerontology concerned with the biological aging process, its evolutionary origins, and potential means to intervene in the process. The term "biogerontology" was coined by S. Rattan, and came in regular use with the start of the journal Biogerontology in 2000. It involves interdisciplinary research on the ...
The hallmarks of aging are the types of biochemical changes that occur in all organisms that experience biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 [1] to conceptualize the essence of biological aging and its underlying ...
Ageing (or aging in American English) is the process of becoming older. The term refers mainly to humans, many other animals, and fungi, whereas for example, bacteria, perennial plants and some simple animals are potentially biologically immortal. [ 1 ] In a broader sense, ageing can refer to single cells within an organism which have ceased ...
Scientific career. Institutions. Shell Oil, Emeryville, California; University of Nebraska. Denham Harman (February 14, 1916 – November 25, 2014) was an American medical academic who latterly served as professor emeritus at the University of Nebraska Medical Center. [1][2][3] Harman is known as the " father of the free radical theory of aging ...
The network theory of aging supports the idea that multiple connected processes contribute to the biology of aging. Kirkwood and Kowald helped to establish the first model of this kind by connecting theories and predicting specific mechanisms. In departure of investigating a single mechanistic cause or single molecules that lead to senescence ...
A. Aging by design theory. Aging theories based on evolvability. Aging theories based on group selection. Antagonistic pleiotropy hypothesis.