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Doxylamine and other first-generation antihistamines are the most widely used sleep medications in the world. [6] Typical side effects of doxylamine (at recommended doses) include dizziness, drowsiness, grogginess, and dry mouth, among others. [7][4] As an antihistamine, doxylamine is an inverse agonist of the histamine H 1 receptor.
Scopolamine, also known as hyoscine, [ 9 ] or Devil's Breath, [ 10 ] is a natural or synthetically produced tropane alkaloid and anticholinergic drug that is used as a medication to treat motion sickness [ 11 ] and postoperative nausea and vomiting. [ 12 ][ 1 ] It is also sometimes used before surgery to decrease saliva. [ 1 ]
Artificial saliva or salivary substitutes refer to a synthetically produced liquid that mimics the natural secretion of saliva. It is designed as a symptomatic relief for xerostomia, a condition characterised by dryness in the mouth and is available over-the-counter. The efficacy of artificial saliva in a systematic review of clinical trials ...
Xerostomia is the subjective sensation of dry mouth, which is often (but not always) associated with hypofunction of the salivary glands. [3] The term is derived from the Greek words ξηρός (xeros) meaning "dry" and στόμα (stoma) meaning "mouth". [4][5] A drug or substance that increases the rate of salivary flow is termed a sialogogue.
The 1550 BC Ebers Papyrus describes tablets to cure bad breath based on incense, cinnamon, myrrh and honey. [35] Hippocratic medicine advocated a mouthwash of red wine and spices to cure bad breath. [36] Alcohol-containing mouthwashes are now thought to exacerbate bad breath as they dry the mouth, leading to increased microbial growth.
1. antagonist. H1 antagonists, also called H1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions. Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic ...
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